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Table 2 Phospholipids fatty acid composition of PUFA-treated MDA-MB-231

From: Effects of n-3 PUFAs on breast cancer cells through their incorporation in plasma membrane

 

C16:0

C16:1

C18:0

C18:1

C18:2

C18:3

C20:3

C20:4

C20:5

C22:5

C22:6

SFA

MUFA

PUFA

n-6 PUFA

n-3 PUFA

Omega-6/Omega-3

AA/EPA

AA/DHA

PE CTR

5.13

0.80

19.58

18.11

3.12

0.62

1.58

30.38

3.65

6.14

7.85

24.71

18.90

53.34

35.08

18.26

1.95

8.96

3.93

s.d.

1.87

0.59

2.40

2.59

0.97

0.19

0.37

4.39

0.90

1.01

1.06

3.16

2.80

4.03

3.42

2.01

0.30

2.99

0.79

PE AA

6.16

1.29

22.60*

15.64*

1.52*

0.30*

1.15*

40.72*

0.66*

3.75*

3.09*

28.76*

16.93*

51.08*

43.39*

7.70*

5.69*

81.49*

13.38*

s.d.

0.86

1.12

0.88

0.84

0.14

0.03

0.35

1.29

0.49

0.74

0.45

1.73

0.52

0.89

1.16

0.80

0.61

37.02

1.79

PE EPA

5.64

0.55

20.44

13.68*

1.66*

0.33*

0.84*

8.13*

22.52*

18.86*

1.62*

26.09

14.23*

53.96

10.63*

43.34*

0.25*

0.36*

5.10

s.d.

1.35

0.24

5.47

0.92

0.35

0.07

0.28

1.21

1.33

2.80

0.26

5.28

1.07

3.47

1.13

3.78

0.04

0.07

1.14

PE DHA

6.44

1.14

19.87

8.80*

1.34*

0.27*

0.84*

12.15*

2.10*

2.26*

42.31*

26.31

10.57*

56.55

13.46*

47.24*

0.26*

6.41

0.25*

s.d.

1.86

0.64

3.99

0.62

0.46

0.09

0.45

2.73

0.71

0.45

3.04

5.38

1.95

7.81

3.21

2.96

0.01

3.60

0.02

PI CTR

4.32

1.31

34.32

14.48

2.50

0.50

2.88

25.54

1.44

4.65

3.98

40.05

14.35

41.67

30.34

11.33

3.23

22.84

8.98

s.d.

1.73

1.31

5.38

4.35

1.74

0.35

0.66

3.93

0.65

1.12

1.74

5.37

5.32

5.09

6.33

3.34

1.68

11.79

9.39

PI AA

8.23*

2.40

33.71

13.31

1.44*

0.29*

0.65*

30.03*

0.40*

2.16*

2.94

41.95

15.26

37.99

32.11

5.87*

5.51*

75.95*

10.23

s.d.

2.67

1.24

2.05

1.54

0.40

0.08

0.30

2.86

0.04

0.15

0.36

3.09

2.39

2.53

2.70

0.40

0.69

15.180

1.75

PI EPA

6.16*

1.12

24.38

14.81

2.34

0.47

1.15*

11.53*

14.30*

16.40*

1.32*

30.55*

15.93

48.87*

15.02*

33.85*

0.45*

0.84*

10.35

s.d.

1.23

0.50

2.72

6.18

1.19

0.24

0.48

3.47

5.28

4.92

0.74

2.27

6.31

6.89

2.60

5.10

0.07

0.15

6.91

PI DHA

10.09*

2.99

32.88

10.90

1.96

0.39

1.81*

10.22*

0.96*

2.55*

20.43*

42.96

13.89

39.71

16.48*

22.57*

0.81*

10.77*

0.53*

s.d.

4.52

1.72

4.57

3.28

0.51

0.10

0.91

3.93

0.24

0.36

2.58

8.07

4.59

6.02

6.13

4.12

0.48

3.14

0.15

PS CTR

6.22

2.16

26.07

23.76

3.69

1.10

2.27

13.12

2.50

5.74

7.52

32.40

24.94

38.00

20.12

16.73

1.25

6.03

1.90

s.d.

1.88

1.96

9.75

6.53

1.62

1.07

0.99

7.67

1.20

1.69

3.71

9.19

7.87

11.64

10.49

4.72

0.68

3.59

1.64

PS AA

13.48*

4.69*

21.00

25.00

2.00*

0.48*

0.29*

14.87

0.41*

1.82*

6.07

34.38

29.80

26.37*

17.81

8.56*

2.12*

47.07*

2.86

s.d.

1.77

1.71

4.77

4.62

0.61

0.21

0.16

4.00

0.23

0.63

1.75

3.20

3.57

4.01

4.27

0.98

0.70

29.02

1.92

PS EPA

6.17

1.38

14.67*

18.78

1.76*

0.35*

1.34

6.96*

16.53*

23.17*

2.48*

27.92

19.97

48.44

10.06*

38.38*

0.29*

0.48*

2.18

s.d.

1.30

0.65

4.30

3.79

0.55

0.11

1.12

4.17

0.34

7.45

0.59

13.86

4.06

13.24

4.27

12.21

0.14

0.27

0.83

PS DHA

11.48*

2.44

28.32

10.43*

1.60*

0.32*

0.42*

9.99

1.23*

2.41*

30.84*

36.77

12.26*

45.48

10.63

34.49*

0.32*

9.65

0.33*

s.d.

3.46

1.48

13.14

1.56

0.29

0.06

0.13

2.22

0.40

0.83

8.78

17.15

3.15

11.23

3.27

8.40

0.09

3.81

0.05

PC CTR

23.82

3.13

13.90

35.51

6.45

1.29

1.43

8.17

1.20

1.88

2.29

37.73

38.64

22.62

16.04

6.58

2.50

7.50

3.86

s.d.

3.82

1.19

2.11

3.70

0.84

0.17

0.37

2.43

0.44

0.64

0.72

3.25

3.55

2.82

2.26

1.15

0.47

3.56

1.43

PC AA

27.29*

3.84

11.20*

21.03*

2.66*

0.53*

1.02*

27.61*

0.10*

1.45*

1.33*

38.50

24.87*

34.80*

31.29*

3.51*

8.89*

277.85*

18.21*

s.d.

1.51

0.42

0.69

1.98

0.18

0.04

0.13

3.19

0.01

0.23

0.28

1.43

2.03

3.27

3.13

0.15

0.56

34.12

2.17

PC EPA

25.10

1.63*

9.05*

20.73*

4.33*

0.87*

0.83*

3.62*

15.71*

14.26*

1.36

34.14

22.36*

40.96*

8.77*

32.17*

0.28*

0.24*

3.42

s.d.

3.84

0.25

1.94

1.79

0.66

0.13

0.42

0.53

2.09

5.43

0.93

4.74

1.92

6.92

0.36

6.75

0.05

0.04

1.29

PC DHA

23.54

2.89

13.68

16.85*

3.07*

0.61*

0.96*

7.16

1.78*

1.80

23.90*

37.41

20.77*

39.77*

11.80*

27.96*

0.43*

4.12*

0.33*

s.d.

2.72

0.88

1.65

3.35

0.37

0.08

0.25

0.98

0.45

0.66

4.15

4.53

1.62

3.56

0.42

3.75

0.08

0.54

0.09

SM CTR

20.03

2.74

14.34

21.96

3.21

0.80

1.11

8.09

1.17

3.16

6.05

33.78

22.98

24.11

12.93

11.18

1.34

11.07

1.73

s.d.

9.10

1.62

8.11

7.61

1.60

0.73

1.09

3.47

1.17

2.87

3.57

16.17

9.73

6.62

4.26

4.31

0.45

7.33

0.83

SM AA

18.75

2.94

10.40

20.80

2.24

0.45

0.53*

12.30*

0.75

0.63*

6.68

33.32

23.22

22.58

14.80

8.45*

1.76*

30.33*

1.86

s.d.

5.27

1.67

1.00

4.33

0.93

0.19

0.15

0.96

0.54

0.34

0.94

14.58

4.99

1.84

1.45

0.29

0.23

10.50

0.26

SM EPA

12.67*

1.99

6.43*

24.50

2.07*

0.41

0.38*

7.85

4.38*

6.28*

2.93*

19.11*

24.70

26.51

13.17

16.24

0.90

1.78*

3.47

s.d.

3.19

0.78

0.67

2.85

0.71

0.14

0.06

2.91

1.67

2.13

1.48

3.51

7.82

6.22

5.26

7.02

0.45

0.83

2.00

SM DHA

19.07

5.01*

14.14

13.62*

2.89

0.58

1.72

5.60*

1.20

1.24*

8.35

33.21

19.47

25.69

10.21*

15.48

0.79*

5.76*

0.70*

s.d.

6.89

0.79

3.32

1.01

0.42

0.08

0.73

1.88

0.53

0.23

2.52

9.19

2.32

7.32

1.37

7.31

0.37

3.21

0.37

  1. Values are expressed as percentage of total fatty acids (means bold numbers, SD plain numbers).
  2. CTR n = 15, Treated n=6; * P < 0.01