Effects of the PBP on suppression of joint and tissue swelling in AA. The paw swellings of rats were evaluated by an inelastic tape measure. All groups treated with PBP showed a 70% decrease in paw swelling compared to model controls, P < 0.05. And peptide treatment groups showed a marked destruction and infiltration compared with model groups. (A: the primary swelling of ankle joint. B: the secondary swelling of ankle joint).