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Figure 2 | Lipids in Health and Disease

Figure 2

From: α-Linolenic acid prevents endoplasmic reticulum stress-mediated apoptosis of stearic acid lipotoxicity on primary rat hepatocytes

Figure 2

α-Linolenic acid protects primary rat hepatocytes against ER stress induced by stearic acid. (A)Western blot and (B) densitometric analysis demonstrating the reduction of stearic acid (SA)-induced GRP78 expression by 150 or 250 μmol/l α-linolenic acid (ALA) after 16 h. (A)Western blot and (C) densitometric analysis of GRP94 expression after 16 h incubation of cells with 250 μmol/l stearic acid(SA) in presence of 150 or 250 μmol/l α-linolenic acid (ALA). (A)Western blot and (D) densitometric analysis demonstrating the reduction of stearic acid (SA)-induced CHOP expression by 150 or 250 μmol/l α-linolenic acid (ALA) after 16 h. Data represent mean ± S.E.M., n = 5, *P < 0.05 vs. LG, low glucose control (0 μmol/l stearic acid), **P < 0.05 vs. stearic acid-only cells.

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