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Table 3 Parameters of lipid metabolism of Wilson disease patients under therapy.

From: Alterations of lipid metabolism in Wilson disease

 

n

Limits of normal

Hepatic

Neurological

Mixed

Asymptomatic

p-value

ALT

249

f: -35 U/l

m: -50 U/l

41

(10-3743)

25

(11-70)

30

(13-99)

24.5

(8-78)

<0.001

AST

250

f: -35 U/l

m: -50 U/l

29

(12-2106)

23

(10-102)

27.9 (12-79)

20

(11-77)

<0.001

Bilirubin

239

< 1.0 mg/dl

0.7

(0.2-23.0)

0.6

(0.2-2.7)

0.7

(0.2-4.5)

0.6

(0.3-1.9)

0.001

Albumin

231

30-50 g/l

44

(21-55)

44.4

(28-56)

44

(30-73)

45.6

(37-54)

0.277

TG

247

< 150 mg/dl

100

(28-888)

95

(29-438)

106.5

(12-221)

93

(29-285)

0.588

Cholesterol

248

< 200 mg/dl

179.5

(90-319)

182

(120-365)

183

(113-273)

188.5

(103-265)

0.780

HDL

124

>50 mg/dl

55

(27-113)

53

(32-103)

57.5

(40-81)

57

(36-84)

0.588

LDL

115

< 160 mg/dl

108

(43-218)

96

(63-229)

98.5

(63-159)

113.5

(74-156)

0.781

Lp(a)

61

< 25 mg/dl

4.8

(5-52.5)

21.4

(4.8-48.5)

4.9

(4.8-55.4)

20.5

(4.8-38.9)

0.016

BMI

166

18.5-25 kg/m²

22.8

(14.2-41.1)

22.1

(17.7-33.7)

23.8

(15.1-32.5)

22.1

(18.7-28.1)

0.839

  1. With improvement of liver function, parameters of lipid metabolism were comparable between patients, independent of initial presentation.