A reduction of CETP activity, not an increase, is associated with modestly impaired postprandial lipemia and increased HDL-Cholesterol in adult asymptomatic women

Table 1 Clinical and genetic characteristics and common carotid IMT of women in the studied groups

Variables/Groups	CETPd (n = 8)	CETPi (n = 6)	CTL (n = 14)
Age (y)	52.5 ± 9.5 ^a	33.8 ± 6.5 ^b	28.6 ± 8.4 ^c
BMI (Kg/m²)	25.4 ± 4.4	23.0 ± 2.2	21.8 ± 1.9
WC (cm)	78.2 ± 14.5	74.7 ± 4.5	72.6 ± 6.9
SBP (mmHg)	116.2 ± 11.9	115.8 ± 4.9	110.8 ± 8.1
DBP (mmHg)	72.5 ± 8.9	76.7 ± 5.2	73.0 ± 7.3
Mean c-IMT (mm)	0.7 ± 0.1	0.6 ± 0.1	0.5 ± 0.1
CETP TaqIB - B1 allele %	50.0 (7)	62.5 (5)	50.0 (12)*
CETP TaqIB - B2 allele %	50.0 (7)	37.5 (3)	50.0 (12)*
CETP I405V - I allele %	64.3 (9)	37.5 (3)	41.7 (10)*
CETP I405V - V allele %	35.7 (5)	62.5 (5)	58.3 (14)*
ApoE-ε(3/3+3/4) %	100.0	100.0	93.0 *

Data as mean ± SD; defined by levels of CETP activity (diminished (d), increased (i) and controls (CTL); BMI, body mass index; WC, waist circumference, SBP, systolic blood pressure; DBP, diastolic blood pressure; c-IMT, mean common carotid intima-media thickness. Mann-Whitney and X²-square tests *(NS); a vs b, p ≤ 0.0001; a vs c p < 0.004; p values corrected for age by ANCOVA Significant differences are shown in bold CETP TaqIB and I405V polymorphisms: frequency of B1 or B2 alleles and of V or I alleles.

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