Clinical characteristics and evaluation of LDL-cholesterol treatment of the Spanish Familial Hypercholesterolemia Longitudinal Cohort Study (SAFEHEART)

Table 1 Baseline characteristics of subjects recruited in SAFEHEART (20 to 79 years old, N = 1852)

	Index Cases N = 387	FHR (+) N = 875	FHR (-) N = 590	P-value
Gender (male)%	52.2	46.3	46.3	0.117
Mean age (years) * (Age range)	49.1 ± 12.9 (20.2-78.0)	44.1 ± 15.2 (20.1-79.0)	41.3 ± 14.7 (20.2-78.5)	< 0.001
Previous Clinical Diagnosis of FH (%)	100	74.6	13.9	< 0.001
History of CVD (%)	21.7	10.6	3.2	< 0.001
Age of first Cardiovascular event (Age range)	42.8 ± 9.7 (24.0-67.0)	50.3 ± 11.6 (28.0-76.0)	53.9 ± 8.5 (39.0-69.0)	< 0.001
Previous LLT (%)	96.9	77.8	18.8	< 0.001
Type 2 Diabetes (%)	2.1	4.0	3.6	0.220
High Blood Pressure (%)	14.7	14.6	12.7	0.531
Tobacco (current/past)(%)	20.2/33.3	32.0/21.0	34.6/17.1	< 0.001
Xanthomas (%)	20.7	12.8	0.0	< 0.001
BMI (Kg/m²) *	26.7 ± 4.3	26.6 ± 5.00	26.2 ± 5.2	0.272
Total cholesterol (mg/dL)*	256.6 ± 71.9	264.6 ± 69.6	213.3 ± 46.4	< 0.001
Triglycerides (mg/dL)**	89.0 (52)	85.0 (56)	85.0 (54)	0.239
LDL-C (mg/dL)*	188.0 ± 69.9	193.8 ± 66.9	131.3 ± 41.4	< 0.001
HDL-C (mg/dL)*	48.6 ± 13.6	50.3 ± 13.9	51.1 ± 13.9	0.001

FH, Familial Hypercholesterolemia; FHR, Familial Hypercholesterolemia relatives; CVD, Cardiovascular Disease; LLT, Lipid lowering therapy; BMI, Body Mass Index; LDL-C, cholesterol transported on low-density lipoproteins; HDL-C, cholesterol transported on High Density Lipoproteins. * values are expressed as Mean and standard deviation; ** values are expressed as Median and interquartilic range.

ISSN: 1476-511X