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Table 1 Effects of dietary supplementation with AqFSC, EtFSC, or fenofibrate on serum lipid profiles in normal and hypercholesterolemic mice

From: Dietary Fructus Schisandrae extracts and fenofibrate regulate the serum/hepatic lipid-profile in normal and hypercholesterolemic mice, with attention to hepatotoxicity

Groups TC (mmo1/L) TG (mmo1/L) HDL (mmo1/L) LDL (mmo1/L)
Normal diet for 13 days
Normal diet 5.13 ± 0.18 1.84 ± 0.11 4.14 ± 0.14 0.33 ± 0.02
1% AqFSC/normal diet 4.90 ± 0.13 1.84 ± 0.08 4.13 ± 0.12 0.38 ± 0.04
4% AqFSC/normal diet 4.86 ± 0.16 2.03 ± 0.12 4.13 ± 0.16 0.38 ± 0.03
1% EtFSC/normal diet 4.89 ± 0.21 1.73 ± 0.07 4.01 ± 0.16 0.38 ± 0.02
4% EtFSC/normal diet 4.89 ± 0.17 1.77 ± 0.10 4.00 ± 0.12 0.39 ± 0.02
0.1% Fenofibrate/normal diet 3.54 ± 0.34* 1.30 ± 0.12* 2.80 ± 0.18* 0.39 ± 0.03
HFCB diet for 13 days
Normal diet 3.97 ± 0.24 1.19 ± 0.15 3.86 ± 0.12 0.33 ± 0.03
HFCB diet 8.71 ± 0.82* 0.31 ± 0.04* 4.59 ± 0.11* 1.96 ± 0.16*
1% AqFsSC/HFCB diet 7.01 ± 0.31 0.66 ± 0.05 5.17 ± 0.25 2.87 ± 0.24
4% AqFSC/HFCB diet 6.62 ± 0.24 0.27 ± 0.03 5.16 ± 0.18 2.56 ± 0.14
1% EtFSC/HFCB diet 8.63 ± 0.68 0.26 ± 0.03 4.87 ± 0.14 2.68 ± 0.10
4% EtFSC/HFCB diet 9.35 ± 0.37 0.27 ± 0.03 5.16 ± 0.12 2.89 ± 0.27
0.1% Fenofibrate/HFCB diet 5.30 ± 0.21 0.67 ± 0.04 5.91 ± 0.32 0.85 ± 0.15
  1. Mice were fed with either normal or high-fat/cholesterol/bill salt (HFCB, 10/1/0.3%, w/w) diet without and with supplementation with the aqueous/ethanolic extract of Fructus Schisandrae chinensis (AqFSC/EtFSC) or fenofibrate at the indicated concentration for 13 days. The concentrations of AqFSC and EtFSC were based on crude herbal material. Serum total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL), and low density lipoprotein (LDL) levels were then measured. Values given are the men ± S.E.M., with n = 10. *Significantly different from the normal diet group (p < 0.05–0.001). significantly different from the hypercholesterolemic mice (p < 0.05–0.001).