|
Measure
|
Study Period
|
Placebo (x ± SE)
|
P valuea
|
LI85008F (x ± SE)
|
P valuea
|
P valueb
|
|---|
|
Body Wt. (Kg)
|
Baseline
|
84.97 ± 2.80
|
< 0.001
|
86.16 ± 2.75
|
< 0.001
|
-
|
|
8 week
|
83.18 ± 2.82
|
81.40 ± 2.69
|
|
Change
|
1.79 ± 0.34
|
-
|
4.76 ± 0.51
|
-
|
< 0.001
|
|
Body Mass Index (kg/m²)
|
Baseline
|
33.00 ± 0.73
|
< 0.001
|
34.41 ± 0.74
|
< 0.001
|
-
|
|
8 week
|
32.30 ± 0.74
|
32.51 ± 0.75
|
|
Change
|
0.70 ± 0.13
|
-
|
1.90 ± 0.19
|
-
|
< 0.001
|
|
Waist Circumference (cm)
|
Baseline
|
108.59 ± 1.99
|
< 0.001
|
106.68 ± 1.67
|
< 0.001
|
-
|
|
8 week
|
97.35 ± 2.53
|
94.16 ± 2.17
|
|
Change
|
11.24 ± 1.95
|
-
|
12.52 ± 1.83
|
-
|
0.6384
|
|
Hip Circum (cm)
|
Baseline
|
119.51 ± 1.50
|
< 0.001
|
117.99 ± 1.67
|
< 0.001
|
-
|
|
8 week
|
110.68 ± 1.85
|
108.07 ± 1.65
|
|
Change
|
8.83 ± 0.99
|
-
|
9.92 ± 1.34
|
-
|
0.0934
|
|
Waist-Hip Ratio (WHR)
|
Baseline
|
0.91 ± 0.01
|
<0.05
|
0.91 ± 0.01
|
<0.05
|
-
|
|
8 week
|
0.88 ± 0.01
|
0.87 ± 0.02
|
|
Change
|
0.03 ± 0.01
|
-
|
0.04 ± 0.01
|
-
|
>0.05
|
|
Systolic B.P. (mmHg)
|
Baseline
|
120.40 ± 3.40
|
0.4341
|
123.33 ± 2.87
|
0.4094
|
-
|
|
8 week
|
118.00 ± 3.04
|
126.19 ± 2.80
|
|
Change
|
2.40 ± 2.93
|
-
|
−2.86 ± 3.39
|
-
|
0.2618
|
|
Diastolic B.P. (mmHg)
|
Baseline
|
76.20 ± 1.95
|
0.7388
|
80.00 ± 2.29
|
0.5614
|
-
|
|
8 week
|
75.50 ± 1.53
|
81.43 ± 2.10
|
|
Change
|
0.70 ± 2.02
|
-
|
−1.43 ± 2.42
|
-
|
0.2146
|
|
Heart Rate (Beats/mim)
|
Baseline
|
73.20 ± 0.62
|
0.5953
|
74.29 ± 0.92
|
0.6676
|
-
|
|
8 week
|
74.00 ± 1.34
|
74.95 ± 0.91
|
|
Change
|
−0.80 ± 1.45
|
-
|
−0.67 ± 1.53
|
-
|
0.4006
|
- a Difference within the group (baseline vs. final evaluation) using paired t-test.
- b Difference between changes (derived from baseline minus final evaluation) in placebo and LI85008F group using unpaired t-test.
