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Table 4 Assessment of association between four SNPs in SLC22A3-LPAL2-LPA region with CHD

From: Lack of association between four SNPs in the SLC22A3-LPAL2-LPA gene cluster and coronary artery disease in a Chinese Han population: a case control study

  

Without Adjustment†

With Adjustment ‡

SNP

Model

P

OR (95%CI)

P

OR (95%CI)

rs2048327

Additive

0.44

0.95(0.83-1.08)

0.56

0.96(0.84-1.10)

 

Dominant

0.84

1.02(0.94-1.24)

0.70

1.04(0.85-1.27)

 

Recessive

0.09

0.81(0.63-1.03)

0.12

0.82(0.63-1.05)

rs3127599

Additive

0.32

1.10(0.91-1.34)

0.53

1.07(0.87-1.31)

 

Dominant

0.37

1.10(0.89-1.36)

0.59

1.60(0.85-1.33)

 

Recessive

0.50

1.32(0.59-2.96)

0.59

1.26(0.55-2.92)

rs7767084

Additive

0.50

1.05(0.91-1.22)

0.19

1.13(0.94-1.37)

 

Dominant

0.26

1.11(0.93-1.33)

0.19

1.13(0.94-1.37)

 

Recessive

0.60

0.91(0.64-1.29)

0.60

0.91(0.63-1.31)

rs10755578

Additive

0.21

0.92(0.80-1.05)

0.29

0.93(0.81-1.07)

 

Dominant

0.84

0.98(0.76-1.25)

0.77

0.96(0.74-1.25)

 

Recessive

0.10

0.85(0.70-1.03)

0.20

0.88(0.72-1.07)

  1. †P values were obtained from univariate logistic regression model where the SNP predictor was coded according to three different genetic models.
  2. ‡P values were multivariate obtained from logistic regression model after adjustment for gender, age, smoking and BMI.
  3. OR, odds ratio; CI, confidence interval.