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Figure 3 | Lipids in Health and Disease

Figure 3

From: Exercise training performed simultaneously to a high-fat diet reduces the degree of insulin resistance and improves adipoR1-2/APPL1 protein levels in mice

Figure 3

Effects of exercise training concomitant to high-fat diet feeding on IR, IRS1, and Akt phosphorylation and adipoR2/APPL1 protein levels in the skeletal muscle . Analysis of insulin-induced tyrosine phosphorylation of IR (A), IRS1 (B), phosphorylation of AktSer473 (C) and ADIPOR2 (D) and APPL1 (E) protein levels. In lower panels, original membrane stripped and reblotted for IR, IRS1, and Akt total protein levels (A, B, and C, respectively) and β-actin (D and E). The results are presented as means ± SEM of n = 6, *p < 0.05, different from C-T and C groups with insulin injection versus C-T and C groups with saline injection, #p < 0.05 different from DIO versus control groups, and $p < 0.05 different from DIO-T versus DIO groups.

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