Table 1 Hemostatic gene expression in human skeletal muscle tissue
GENE | Access # | Expression | Frequency | P-value | Function |
|---|---|---|---|---|---|
COAGULANT FUNCTIONS | |||||
Coagulation factor VIII, procoagulant component | NM_000132.2 | Strong detection | 8/8 | 0.00024 | Intrinsic pathway of blood coagulation |
Coagulation factor VII | NM_000131.2 | Strong detection | 8/8 | 0.0016 | Activates the coagulation cascade by converting factor IX to factor IXa factor X to factor Xa coagulation factor VII |
Vitamin K epoxide reductase complex, subunit 1-like 1 | NM_173517 | Strong detection | 8/8 | 0.0016 | Paralog of vitamin K epoxide reductase complex, subunit 1 |
Coagulation factor VIII-associated (intronic transcript) | NM_012151.2 | Strong detection | 8/8 | 0.0020 | unknown |
von Willebrand factor (VWF) | NM_000552.2 | Strong detection | 8/8 | 0.005 | Serves as a bridge between platelet glycoprotein GPIb/IX and collagen |
Vitamin K epoxide reductase complex, subunit 1 | NM_024006 | Moderate detection | 8/8 | 0.014 | Required for the carboxylation of glutamic acid residues in some blood-clotting proteins |
Gamma-glutamyl carboxylase | BE326952 | Moderate detection | 7/8 | 0.024 | Carboxylation of coagulation factors VII |
4/8 | 0.063 | ||||
Glycoprotein Ib (platelet), alpha polypeptide | NM_000173 | Moderate detection | 4/8 | 0.051 | Binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury |
Coagulation factor XIII, A1 polypeptide | NM_000129.2 | Moderate detection | 3/8 | 0.068 | Last zymogen to become activated in the blood coagulation cascade |
Thrombin receptor | NM_001992.2 | Moderate detection | 4/8 | 0.071 | Activated on surface of activated platelets by prothrombinase complex |
Integrin, beta 3 | NM_000212 | Moderate detection | 3/8 | 0.076 | Promotion of the generation of thrombin by localizing prothrombin to cellular surfaces |
3/8 | 0.081 | ||||
ANTI-COAGULANT FUNCTIONS | |||||
Platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit | NM_000430.2 | Strong detection | 8/8 | 0.00024 | Catalyzes the removal of the acetyl group at the SN-2 position of platelet-activating factor |
8/8 | 0.00354 | ||||
7/8 | 0.011 | ||||
6/8 | 0.027 | ||||
4/8 | 0.051 | ||||
Annexin A5 | NM_001154 | Strong detection | 8/8 | 0.0012 | Forms a two-dimensional protective shield, covering exposed potentially thrombogenic cell surfaces |
Tissue factor pathway inhibitor | J03225.1 | Strong detection | 6/8 | 0.004 | Inhibits tissue factor |
3/8 | 0.076 | ||||
Protein C receptor, endothelial | 34335271 | Strong detection | 8/8 | 0.0044 | N-glycosylated type I membrane protein that enhances the activation of protein C |
Thrombomodulin | 40288292 | Moderate detection | 7/8 | 0.024 | Receptor that binds thrombin activating protein C and degrades clotting factors Va and VIIIa |
Protein S (alpha) | NM_000313 | Moderate detection | 7/8 | 0.024 | A cofactor to anticoagulant activated protein C |
Ectonucleoside triphosphate diphosphohydrolase 1 | NM_001776 | Moderate detection | 1/8 | 0.081 | Endothelial ecto-ADPase inhibiting platelet function via hydrolysis of released platelet ADP |
FIBRINOLYTIC FUNCTIONS | |||||
Annexin A2 | NM_004039 | Strong detection | 8/8 | 0.00024 | Profibrinolytic co-receptor for tissue plasminogen activator and plasminogen on endothelial cells |
0.00024 | |||||
0.00024 | |||||
Tetranectin (plasminogen-binding protein) | NM_003278 | Strong detection | 8/8 | 0.0022 | Bind fibrin and coactivate plasminogen |
Plasminogen activator, urokinase | NM_002658 | Moderate detection | 7/8 | 0.024 | Conversion of plasminogen to plasmin |
4/8 | 0.051 | ||||
Plasminogen activator, tissue | NM_000930 | Moderate detection | 7/8 | 0.031 | Conversion of plasminogen to plasmin |
Urokinase plasminogen activator receptor | X74039.1 | Moderate detection | 5/8 | 0.046 | Binds uPA and permits activation of pro-enzyme by plasmin |