Skip to main content

Table 1 Hemostatic gene expression in human skeletal muscle tissue

From: Identification of hemostatic genes expressed in human and rat leg muscles and a novel gene (LPP1/PAP2A) suppressed during prolonged physical inactivity (sitting)

GENE Access # Expression Frequency P-value Function
COAGULANT FUNCTIONS
Coagulation factor VIII, procoagulant component NM_000132.2 Strong detection 8/8 0.00024 Intrinsic pathway of blood coagulation
Coagulation factor VII NM_000131.2 Strong detection 8/8 0.0016 Activates the coagulation cascade by converting factor IX to factor IXa factor X to factor Xa coagulation factor VII
Vitamin K epoxide reductase complex, subunit 1-like 1 NM_173517 Strong detection 8/8 0.0016 Paralog of vitamin K epoxide reductase complex, subunit 1
Coagulation factor VIII-associated (intronic transcript) NM_012151.2 Strong detection 8/8 0.0020 unknown
von Willebrand factor (VWF) NM_000552.2 Strong detection 8/8 0.005 Serves as a bridge between platelet glycoprotein GPIb/IX and collagen
Vitamin K epoxide reductase complex, subunit 1 NM_024006 Moderate detection 8/8 0.014 Required for the carboxylation of glutamic acid residues in some blood-clotting proteins
Gamma-glutamyl carboxylase BE326952 Moderate detection 7/8 0.024 Carboxylation of coagulation factors VII
4/8 0.063
Glycoprotein Ib (platelet), alpha polypeptide NM_000173 Moderate detection 4/8 0.051 Binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury
Coagulation factor XIII, A1 polypeptide NM_000129.2 Moderate detection 3/8 0.068 Last zymogen to become activated in the blood coagulation cascade
Thrombin receptor NM_001992.2 Moderate detection 4/8 0.071 Activated on surface of activated platelets by prothrombinase complex
Integrin, beta 3 NM_000212 Moderate detection 3/8 0.076 Promotion of the generation of thrombin by localizing prothrombin to cellular surfaces
3/8 0.081
ANTI-COAGULANT FUNCTIONS
Platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit NM_000430.2 Strong detection 8/8 0.00024 Catalyzes the removal of the acetyl group at the SN-2 position of platelet-activating factor
8/8 0.00354
7/8 0.011
6/8 0.027
4/8 0.051
Annexin A5 NM_001154 Strong detection 8/8 0.0012 Forms a two-dimensional protective shield, covering exposed potentially thrombogenic cell surfaces
Tissue factor pathway inhibitor J03225.1 Strong detection 6/8 0.004 Inhibits tissue factor
3/8 0.076
Protein C receptor, endothelial 34335271 Strong detection 8/8 0.0044 N-glycosylated type I membrane protein that enhances the activation of protein C
Thrombomodulin 40288292 Moderate detection 7/8 0.024 Receptor that binds thrombin activating protein C and degrades clotting factors Va and VIIIa
Protein S (alpha) NM_000313 Moderate detection 7/8 0.024 A cofactor to anticoagulant activated protein C
Ectonucleoside triphosphate diphosphohydrolase 1 NM_001776 Moderate detection 1/8 0.081 Endothelial ecto-ADPase inhibiting platelet function via hydrolysis of released platelet ADP
FIBRINOLYTIC FUNCTIONS
Annexin A2 NM_004039 Strong detection 8/8 0.00024 Profibrinolytic co-receptor for tissue plasminogen activator and plasminogen on endothelial cells
0.00024
0.00024
Tetranectin (plasminogen-binding protein) NM_003278 Strong detection 8/8 0.0022 Bind fibrin and coactivate plasminogen
Plasminogen activator, urokinase NM_002658 Moderate detection 7/8 0.024 Conversion of plasminogen to plasmin
4/8 0.051
Plasminogen activator, tissue NM_000930 Moderate detection 7/8 0.031 Conversion of plasminogen to plasmin
Urokinase plasminogen activator receptor X74039.1 Moderate detection 5/8 0.046 Binds uPA and permits activation of pro-enzyme by plasmin
  1. Access # is NCBI accession number. Frequency is the number of biopsy samples showing significant expression out of a total number of 8 biopsies according to Affymetrix criteria. P-value is the median p-value of the Wilcoxon test for all 8 human biopsy samples. The gene was bolded and the p-value was underlined if it met the FDR criteria for being significantly detected. Multiple probe sets are available for some genes and are presented in the Table.