Skip to main content

Table 2 Hemostatic gene expression in rat skeletal muscle tissue

From: Identification of hemostatic genes expressed in human and rat leg muscles and a novel gene (LPP1/PAP2A) suppressed during prolonged physical inactivity (sitting)

GENE Access # Expression Frequency P-value Function
COAGULANT FUNCTIONS
Tissue factor U07619 Strong detection 8/8 0.0013 Initiates blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII
Fibulin 5 NM_019153 Strong detection 8/8 0.0014 Forms complex with fibrinogen
Thrombin receptor M81642 Strong detection 8/8 0.0066 Activated on surface of activated platelets by prothrombinase complex
Gamma-glutamyl carboxylase AF065387 Strong detection 7/8 0.021 Carboxylation of coagulation factors VII
P2Y purinoceptor U22830 Moderate detection 5/8 0.031 Binds ADP and leads to platelet shape change
Coagulation factor IX M26247 Moderate detection 2/8 0.058 Vit K dependent factor that activates factor X
Fibrinogen-gamma J00735 Moderate detection 1/8 0.090 Fibrinogen is cleaved by thrombin to form fibrin
ANTI-COAGULANT FUNCTIONS
Annexin A5 D42137 Strong detection 8/8 0.00043 Forms a two-dimensional protective shield, covering exposed potentially thrombogenic cell surfaces
Ectonucleoside triphosphate diphosphohydrolase1 NM_022587 Moderate detection 4/8 0.040 Endothelial ecto-ADPase inhibiting platelet function via hydrolysis of released platelet ADP
Protein S (alpha) U06230 Moderate detection 2/8 0.044 A cofactor to anticoagulant activated protein C
Thrombomodulin AF022742 Moderate detection 6/8 0.052 Receptor that binds thrombin activating protein C and degrades clotting factors Va and VIIIa
FIBRINOLYTIC FUNCTIONS
Plasminogen activator, tissue M23697 Strong detection 8/8 0.00027 Conversion of plasminogen to plasmin
Annexin A2 L13039 Strong detection 8/8 0.00064 Profibrinolytic co-receptor for tissue plasminogen activator and plasminogen on endothelial cells
Plasminogen activator, urokinase X63434 Strong detection 8/8 0.0026 Conversion of plasminogen to plasmin
  1. Access # is NCBI accession number. Frequency is the number of pools of muscle (n = 10 rats per pool) showing significant expression out of a total number of 8 pools of mRNA. P-value is the median p-value of a Wilcoxon test for all 8 muscle pools. The gene was bolded and the p-value was underlined if it met the FDR criteria for being significantly detected.