COAGULANT FUNCTIONS
|
Tissue factor
|
U07619
|
Strong detection
|
8/8
|
0.0013
|
Initiates blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII
|
Fibulin 5
|
NM_019153
|
Strong detection
|
8/8
|
0.0014
|
Forms complex with fibrinogen
|
Thrombin receptor
|
M81642
|
Strong detection
|
8/8
|
0.0066
|
Activated on surface of activated platelets by prothrombinase complex
|
Gamma-glutamyl carboxylase
|
AF065387
|
Strong detection
|
7/8
|
0.021
|
Carboxylation of coagulation factors VII
|
P2Y purinoceptor
|
U22830
|
Moderate detection
|
5/8
|
0.031
|
Binds ADP and leads to platelet shape change
|
Coagulation factor IX
|
M26247
|
Moderate detection
|
2/8
|
0.058
|
Vit K dependent factor that activates factor X
|
Fibrinogen-gamma
|
J00735
|
Moderate detection
|
1/8
|
0.090
|
Fibrinogen is cleaved by thrombin to form fibrin
|
ANTI-COAGULANT FUNCTIONS
|
Annexin A5
|
D42137
|
Strong detection
|
8/8
|
0.00043
|
Forms a two-dimensional protective shield, covering exposed potentially thrombogenic cell surfaces
|
Ectonucleoside triphosphate diphosphohydrolase1
|
NM_022587
|
Moderate detection
|
4/8
|
0.040
|
Endothelial ecto-ADPase inhibiting platelet function via hydrolysis of released platelet ADP
|
Protein S (alpha)
|
U06230
|
Moderate detection
|
2/8
|
0.044
|
A cofactor to anticoagulant activated protein C
|
Thrombomodulin
|
AF022742
|
Moderate detection
|
6/8
|
0.052
|
Receptor that binds thrombin activating protein C and degrades clotting factors Va and VIIIa
|
FIBRINOLYTIC FUNCTIONS
|
Plasminogen activator, tissue
|
M23697
|
Strong detection
|
8/8
|
0.00027
|
Conversion of plasminogen to plasmin
|
Annexin A2
|
L13039
|
Strong detection
|
8/8
|
0.00064
|
Profibrinolytic co-receptor for tissue plasminogen activator and plasminogen on endothelial cells
|
Plasminogen activator, urokinase
|
X63434
|
Strong detection
|
8/8
|
0.0026
|
Conversion of plasminogen to plasmin
|