Identification of hemostatic genes expressed in human and rat leg muscles and a novel gene (LPP1/PAP2A) suppressed during prolonged physical inactivity (sitting)

Zderic, Theodore W; Hamilton, Marc T

doi:10.1186/1476-511X-11-137

Table 2 Hemostatic gene expression in rat skeletal muscle tissue

From: Identification of hemostatic genes expressed in human and rat leg muscles and a novel gene (LPP1/PAP2A) suppressed during prolonged physical inactivity (sitting)

GENE	Access #	Expression	Frequency	P-value	Function
COAGULANT FUNCTIONS
Tissue factor	U07619	Strong detection	8/8	0.0013	Initiates blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII
Fibulin 5	NM_019153	Strong detection	8/8	0.0014	Forms complex with fibrinogen
Thrombin receptor	M81642	Strong detection	8/8	0.0066	Activated on surface of activated platelets by prothrombinase complex
Gamma-glutamyl carboxylase	AF065387	Strong detection	7/8	0.021	Carboxylation of coagulation factors VII
P2Y purinoceptor	U22830	Moderate detection	5/8	0.031	Binds ADP and leads to platelet shape change
Coagulation factor IX	M26247	Moderate detection	2/8	0.058	Vit K dependent factor that activates factor X
Fibrinogen-gamma	J00735	Moderate detection	1/8	0.090	Fibrinogen is cleaved by thrombin to form fibrin
ANTI-COAGULANT FUNCTIONS
Annexin A5	D42137	Strong detection	8/8	0.00043	Forms a two-dimensional protective shield, covering exposed potentially thrombogenic cell surfaces
Ectonucleoside triphosphate diphosphohydrolase1	NM_022587	Moderate detection	4/8	0.040	Endothelial ecto-ADPase inhibiting platelet function via hydrolysis of released platelet ADP
Protein S (alpha)	U06230	Moderate detection	2/8	0.044	A cofactor to anticoagulant activated protein C
Thrombomodulin	AF022742	Moderate detection	6/8	0.052	Receptor that binds thrombin activating protein C and degrades clotting factors Va and VIIIa
FIBRINOLYTIC FUNCTIONS
Plasminogen activator, tissue	M23697	Strong detection	8/8	0.00027	Conversion of plasminogen to plasmin
Annexin A2	L13039	Strong detection	8/8	0.00064	Profibrinolytic co-receptor for tissue plasminogen activator and plasminogen on endothelial cells
Plasminogen activator, urokinase	X63434	Strong detection	8/8	0.0026	Conversion of plasminogen to plasmin

Access # is NCBI accession number. Frequency is the number of pools of muscle (n = 10 rats per pool) showing significant expression out of a total number of 8 pools of mRNA. P-value is the median p-value of a Wilcoxon test for all 8 muscle pools. The gene was bolded and the p-value was underlined if it met the FDR criteria for being significantly detected.

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