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Table 3 LPP1 related gene expression in human skeletal muscle

From: Identification of hemostatic genes expressed in human and rat leg muscles and a novel gene (LPP1/PAP2A) suppressed during prolonged physical inactivity (sitting)

GENE Access # Expression Frequency P-value Function
GENE SUPPRESSED BY PHYSICAL INACTIVITY
LPP1 AB000888.1 Strong detection 8/8 0.004 Dephosphorylates LPA, S1P, PA, ceramide-1-P
GENES NOT AFFECTED BY PHYSICAL INACTIVITY
LPP2 AF047760.1 Not detected 0/8 0.47 Dephosphorylates LPA, S1P, PA, ceramide-1-P
LPP3 NM_003713 Strong detection 8/8 0.0007 Dephosphorylates LPA, S1P, PA, ceramide-1-P
8/8 0.0002
LPAP AB031478.1 Moderate detection 2/8 0.068 Dephosphorylates LPA
SGPP1 NM_030791 Moderate detection 7/8 0.024 Dephosphorylates S1P
SGPL1 NM_003901.1 Not detected 0/8 0.90 Irreversible sphingosine 1-phosphate degradation
SPHK1 NM_021972.1 Not detected 0/8 0.19 Phosphorylates sphingosine
AGPAT1 U56417 Strong detection 8/8 0.0029 ER enzyme converting LPA to PA
8/8 0.0056
AGPAT2 U56418 Moderate detection 8/8 0.028 ER enzyme converting LPA to PA
AGPAT3 NM_020132 Strong detection 8/8 0.002 ER enzyme converting LPA to PA
AGPAT4 NM_020133.1 Not detected 0/8 0.25 Converts LPA to PA
LYPLA1 AF077198.1 Strong detection 8/8 0.0002 Hydrolyzes lysophosphatidylcholine to LPA
LYPLA2 NM_007260.1 Strong detection 8/8 0.014 Hydrolyzes lysophosphatidylcholine to LPA
EDG2 45580697 Moderate detection 4/8 0.068 LPA receptor
EDG3 NM_005226 Not detected 0/8 0.43 LPA receptor
EDG4 NM_004720.3 Not detected 0/8 0.63 LPA receptor
EDG7 NM_012152.1 Not detected 0/8 0.33 LPA receptor
EDG8 AF317676 Not detected 0/8 0.97 S-1-P receptor
P2Y9 NM_005296.1 Not detected 0/8 0.63 LPA receptor, platelet
ROCK2 D87931 Strong detection 7/8 0.010 LPA activated kinase
  1. Access # is NCBI accession number. Frequency is the number of biopsy samples showing significant expression out of a total number of 8 biopsies. P-value is the median p-value of a Wilcoxon test for all 8 human biopsy samples. The gene was bolded and the p-value was underlined if it met the FDR criteria for being significantly detected. Multiple probe sets are available for some genes and are presented in the Table. ER, endoplasmic reticulum; LPA, lysophosphatidic acid; S1P, sphingosine-1-phosphate; PA, phosphatidic acid LPA, lysophosphatidic acid; S1P, sphingosine-1-phosphate; PA, phosphatidic acid; AGPAT, 1-acylglycerol-3-phosphate acyltransferase; EDG, endothelial differentiation gene; LPAP, LPA phosphatase; LPP, lipid phosphate phosphatase; LYPLA, lysophospholipase; ROCK2, Rho-associated, coiled-coil containing protein kinase 2; SGPL1, sphingosine-1-phosphate lyase 1; SGPP1, sphingosine-1-phosphatase; SPHK1, sphingosine kinase 1.