Visit | Dose | Body weight (lb) | Systolic BP (mmHg) | Diastolic BP (mmHg) | ||||||
---|---|---|---|---|---|---|---|---|---|---|
Mean ± SD | median | p vs Visit 0 | Mean ± SD | median | p vs Visit 0 | Mean ± SD | median | p vs Visit 0 | ||
0 | 0 | 209 ±51 | 216 | 126 ±19 | 120 | 86 ±14 | 80 | |||
1 | 4 | 202 ±54 | 214 | 116 ±15 | 110 | 75 ±11 | 80 | .05 | ||
2 | 4 | 202 ±51 | 214 | 110 ±7 | 110 | .04 | 77 ±8 | 80 | ||
3 | 4 | 199 ±49 | 211 | 116 ±14 | 110 | 78 ±13 | 76 | |||
4 | 4 | 199 ±50 | 209 | 121 ±17 | 130 | 74 ±10 | 78 | .05 | ||
5 | 4 | 202 ±51 | 214 | 122 ±13 | 118 | 78 ±5 | 80 | |||
6 | 4 | 201 ±60 | 225 | 122 ±2 | 122 | 77 ±6 | 80 | |||
7 | 4 | 201 ±59 | 224 | 120 ±12 | 116 | 77 ±6 | 77 | |||
In 7 subjects, where the Lovaza sequence was 4, 8, 12, 4, 4, 4,4 g/day | ||||||||||
Visit | Dose | Body weight (lb) | Systolic BP (mmHg) | Diastolic BP (mmHg) | ||||||
Mean ± SD | median | p vs Visit 0 | Mean ± SD | median | p vs Visit 0 | Mean ± SD | median | p vs Visit 0 | ||
0 | 0 | 251 ±30 | 246 | 138 ±28 | 124 | 88 ±13 | 86 | |||
1 | 4 | 251 ±31 | 246 | 139 ±25 | 132 | 88 ± 9 | 86 | |||
2 | 8 | 253 ±28 | 247 | 129 ±23 | 124 | 85 ±18 | 78 | |||
3 | 12 | 250 ±29 | 242 | 122 ±10 | 122 | 84 ±17 | 80 | |||
4 | 4 | 250 ±31 | 242 | 121 ±12 | 120 | .05 | 79 ± 8 | 80 | .05 | |
5 | 4 | 251 ±29 | 249 | 130 ±16 | 130 | 85 ±12 | 82 | |||
6 | 4 | 247 ±33 | 244 | 136 ±24 | 132 | 83 ±14 | 80 | |||
7 | 4 | 243 ±34 | 235 | .002 | 132 ±24 | 124 | 78 ±12 | 76 | .02 | |
In 3 non-responders, where the Lovaza sequence was 4, 8, 12, 4, 4, 4, 4 g/day | ||||||||||
Visit | Dose | Body weight (lb) | Systolic BP (mmHg) | Diastolic BP (mmHg) | ||||||
Mean ± SD | median | p vs Visit 0 | Mean ± SD | median | p vs Visit 0 | Mean ± SD | median | p vs Visit 0 | ||
0 | 0 | 204 ±10 | 204 | 121 ±17 | 120 | 84 ±4 | 85 | |||
1 | 4 | 202 ±11 | 196 | 115 ±15 | 110 | 77 ±7 | 76 | |||
2 | 8 | 198 ±14 | 191 | 122 ±3 | 120 | 87 ±6 | 90 | |||
3 | 12 | 200 ±14 | 195 | 125 ±8 | 120 | 82 ±5 | 84 | |||
4 | 4 | 198 ±13 | 192 | 113 ±12 | 120 | 76 ±4 | 75 | |||
5 | 4 | 196 ±12 | 190 | .02 | 126 ±14 | 134 | 79 ±10 | 77 | ||
6 | 4 | 204 ±11 | 204 | 129 ±1 | 129 | 82 ±0 | 82 | |||
7 | 4 | 202 ±19 | 202 | 123 ±24 | 123 | 82 ±11 | 82 |