Table 3 Body weight and blood pressure at each visit in 5 subjects, where the Lovaza sequence was 4,4,4,4,4,4,4 g/day

0

0

209 ±51

216

126 ±19

120

86 ±14

80

1

4

202 ±54

214

116 ±15

110

75 ±11

80

.05

2

4

202 ±51

214

110 ±7

110

.04

77 ±8

80

3

4

199 ±49

211

116 ±14

110

78 ±13

76

4

4

199 ±50

209

121 ±17

130

74 ±10

78

.05

5

4

202 ±51

214

122 ±13

118

78 ±5

80

6

4

201 ±60

225

122 ±2

122

77 ±6

80

7

4

201 ±59

224

120 ±12

116

77 ±6

77

In 7 subjects, where the Lovaza sequence was 4, 8, 12, 4, 4, 4,4 g/day

Visit

Dose

Body weight (lb)

Systolic BP (mmHg)

Diastolic BP (mmHg)

Mean ± SD

median

p vs Visit 0

Mean ± SD

median

p vs Visit 0

Mean ± SD

median

p vs Visit 0

0

0

251 ±30

246

138 ±28

124

88 ±13

86

1

4

251 ±31

246

139 ±25

132

88 ± 9

86

2

8

253 ±28

247

129 ±23

124

85 ±18

78

3

12

250 ±29

242

122 ±10

122

84 ±17

80

4

4

250 ±31

242

121 ±12

120

.05

79 ± 8

80

.05

5

4

251 ±29

249

130 ±16

130

85 ±12

82

6

4

247 ±33

244

136 ±24

132

83 ±14

80

7

4

243 ±34

235

.002

132 ±24

124

78 ±12

76

.02

In 3 non-responders, where the Lovaza sequence was 4, 8, 12, 4, 4, 4, 4 g/day

Visit

Dose

Body weight (lb)

Systolic BP (mmHg)

Diastolic BP (mmHg)

Mean ± SD

median

p vs Visit 0

Mean ± SD

median

p vs Visit 0

Mean ± SD

median

p vs Visit 0

0

0

204 ±10

204

121 ±17

120

84 ±4

85

1

4

202 ±11

196

115 ±15

110

77 ±7

76

2

8

198 ±14

191

122 ±3

120

87 ±6

90

3

12

200 ±14

195

125 ±8

120

82 ±5

84

4

4

198 ±13

192

113 ±12

120

76 ±4

75

5

4

196 ±12

190

.02

126 ±14

134

79 ±10

77

6

4

204 ±11

204

129 ±1

129

82 ±0

82

7

4

202 ±19

202

123 ±24

123

82 ±11

82