The role of Odontella aurita, a marine diatom rich in EPA, as a dietary supplement in dyslipidemia, platelet function and oxidative stress in high-fat fed rats

Table 8 Phospholipid fatty acid composition in liver rat after 7 weeks of diet

Diet groups	C	COA	HF	HFOA	p value
Fatty acids (% molar)
14:0	0.31 ± 0.18	0.18 ± 0.04	0.14 ± 0.03	0.16 ± 0.07	N.S
16:0	17.86 ± 1.69^a	17.15 ± 0.90^a	14.97 ± 0.54^b	14.99 ± 1.14^b	< 0.001
16:1	0.20 ± 0.07	0.16 ± 0.06	0.15 ± 0.05	0.14 ± 0.03	N.S
18:0	21.82 ± 2.05^b	21.99 ± 1.11^b	26.98 ± 0.39^a	26.57 ± 0.69^a	< 0.001
18:1n-7 + n-9	9.12 ± 1.05^a	8.76 ± 0.51^a	7.30 ± 0.77^b	7.15 ± 0.68^b	0.001
18:2n-6	8.80 ± 0.93	9.48 ± 0.96	9.65 ± 0.61	9.43 ± 0.54	N.S
18:3n-3	0.10 ± 0.03	0.10 ± 0.01	0.07 ± 0.01	0.09 ± 0.03	N.S
20:1n-9	0.14 ± 0.05	0.13 ± 0.03	0,12 ± 0.04	0.10 ± 0.03	N.S
20:4n-6	27.80 ± 1.83^ab	26.31 ± 1.64^b	29.37 ± 0.60^a	28.57 ± 1.62^a	0.044
20:5n-3	0.14 ± 0.04^bc	0.28 ± 0.07^a	0.12 ± 0.03^c	0.20 ± 0.03^b	< 0.001
22:5n-3	0.57 ± 0.08^b	0.66 ± 0.09^ab	0.61 ± 0.06^b	0.71 ± 0.09^a	0.038
22:6n-3	7.79 ± 0.50^a	7.80 ± 0.30^a	6.94 ± 0.60^b	7.46 ± 0.39^ab	0.025
SFA	39.99 ± 0.83^b	39.47 ± 0.59^b	42.14 ± 0.67^a	41.77 ± 0.67^a	< 0.001
MUFA	9.65 ± 1.00^a	9.04 ± 0.55^a	6.83 ± 0.90^b	7.62 ± 0.75^b	< 0.001
Total n-3	8.47 ± 0.49^a	8.81 ± 0.47^a	7.68 ± 0.65^b	8.35 ± 0.29^a	0.009
Total n-6	36.60 ± 1.03^b	37.57 ± 0.95^ab	38.99 ± 0.5^a	38.00 ± 1.34^ab	0.025
Δ9 desaturase index	0.29 ± 0.04^a	0.29 ± 0.02^a	0.20 ± 0.03^b	0.21 ± 0.02^b	0.002
MUFA / SFA	0.25 ± 0.04^a	0.23 ± 0.02^a	0.17 ± 0.02^b	0.17 ± 0.01^b	< 0.001
n-6 / n-3	4.32 ± 0.18^b	4.15 ± 0.30^b	5.13 ± 0.52^a	4.55 ± 0.24^b	0.002

Results are expressed as mean ± SD (n=5). After a one-way ANOVA, Student–Newman–Keuls (SNK) multiple comparison test, results are arranged in increasing order from left to right: a > b > c (p < 0.05). C, control; COA, control + O. aurita; HF, high fat; HFOA, high fat + O. aurita. N.S: Not significant. Δ9 desaturase index = [18:1n-7 + n-9/(18:0 + 18:1n-7 + n-9)].

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