eNOS genotype modifies the effect of leisure-time physical activity on serum triglyceride levels in a Japanese population

Table 3 The NOS 3 T-786C polymorphism and hypertriglyceridemia (serum triglyceride levels ≥ 150)

	TC+CC)vs. TT, model^a1			(TC+CC)vs. TT, model^b2
	OR	95%CI	Interaction	OR	95%	Interaction
	OR	95%CI	P value	OR	95%	P value
Total (n = 2226)	0.80	0.61-1.05		0.78	0.59-1.03
BMI (kg/m²)
< 25 (n = 1645)	0.76	0.54-1.06	0.63	0.75	0.54-1.06	0.55
≥ 25 (n = 581)	0.85	0.53-1.36		0.89	0.55-1.44	0.55
Cumulative smoking exposure
Pack-years < 20 (n = 1679)	0.83	0.60-1.16	0.72	0.81	0.58-1.14	0.64
Pack-years ≥ 20 (n = 547)	0.73	0.45-1.18		0.69	0.41-1.13	0.64
Leisure-time physical activity^c
Sedentary (n = 1349)	1.01	0.72-1.42	0.03	1.03	0.72-1.46	0.01
Active (n = 877)	0.55	0.35-0.88		0.49	0.31-0.80	0.01
Fasting (n = 1417)	0.83	0.58-1.18		0.80	0.58-1.16
BMI (kg/m²)
< 25 (n = 1067)	0.76	0.48-1.18	0.68	0.73	0.46-1.14	0.58
≥ 25 (n = 350)	0.90	0.49-1.64		0.92	0.50-1.70	0.58
Cumulative smoking exposure
Pack-years < 20 (n = 1059)	0.86	0.54-1.35	0.68	0.81	0.51-1.29	0.74
Pack-years ≥ 20 (n = 358)	0.74	0.42-1.32		0.75	0.41-1.36	0.74
Leisure-time physical activity^c
Sedentary (n = 872)	1.17	0.76-1.80	0.008	0.18	0.75-1.86	0.007
Active (n = 545)	0.43	0.22-0.83		0.43	0.22-0.84	0.007

CI, confidence interval; OR, odds ratio.
^a Adjusted for age (continuous), sex (male and female), and enrollment area (Shizuoka, Aichi, Shiga, Kyoto, Tokushima, Fukuoka, Saga and Kagoshima.
^b Adjusted for age, sex, enrollment area, BMI (continuous), fat energy ratio (continuous), smoking habits (never, light, moderate, and heavy), leisure-time physical activity (sedentary, moderate active, and very active), and blood sampling time from last meal (≥ 12 h, 8 h to < 12 h, 4 h to < 8 h, and 2 h to < 4 h).
^c Sedentary, metabolic equivalent (MET)-minutes/week < 600; Active, MET-minutes/week ≥ 600.

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