Table 2 Within sib pair association statistics for seven SNPs with various lipid traits
From: Evaluation of seven common lipid associated loci in a large Indian sib pair study
Gene | Reference for test SNP | Effect Size from European GWAS | SNP (Minor allele frequency) | Phenotype associated with test SNP in previous GWAS | Triglyceride | Total Cholesterol | HDL-cholesterol | LDL-cholesterol |
|---|---|---|---|---|---|---|---|---|
APOA5 | [10] | 16.88 mg/dl [10] | rs662799 (G=0.19) | Triglyceride | 0.18 (0.11, 0.25, p=1.97 x 10-7) | 0.08 (0.02, 0.14, p=0.01) | −0.04 (−0.10, 0.02, p=0.21) | 0.05 (−0.01, 0.12, p=0.12) |
APOB | [9] | 4.89 mg/dl [9] | rs562338 (A=0.13) | LDL-Cholesterol | −0.006 (−0.09, 0.07, p=0.87) | −0.08 (−0.15, -0.002, p=0.04) | 0.03 (−0.04, 0.10, p=0.44) | −0.09 (−0.17, -0.01, p=0.03) |
CETP | [10] | 4.12 mg/dl [10] | rs1864163 (A=0.20) | HDL-Cholesterol | −0.004 (−0.07, 0.07 , p=0.90) | −0.05 (−0.12, 0.01, p=0.12) | −0.01 (−0.08, 0.05, p=0.65) | −0.05 (−0.11, 0.02, p=0.18) |
GCKR | [10] | 8.59 mg/dl [10] | rs780094 (T=0.21) | Triglyceride | 0.11 (0.05, 0.18, p=0.001) | 0.11 (0.05, 0.17, p=3.9x10-4) | 0.04 (−0.01, 0.10, p=0.15) | 0.07 (0.004, 0.13, p=0.03) |
LDLR | [4] | −6.99 mg/d [4] | rs6511720 (T=0.07) | LDL-Cholesterol | 0.005 (−0.11, 0.012, p=0.93) | −0.06 (−0.17, 0.05, p=0.28) | 0.04 (−0.06, 0.15, p=0.39) | −0.06 (−0.18, 0.04, p=0.24) |
LIPC | [10] | 1.38 mg/dl [10] | rs4775041 (C=0.21) | HDL-Cholesterol | 0.03 (−0.04, 0.10, p=0.40) | 0.006 (−0.05, 0.07, p=0.84) | 0.08 (0.02, 0.14, p=0.007) | −0.03 (−0.09, 0.03, p=0.35) |
LPL | [10] | 2.09 mg/dl [10] | rs10503669 (A=0.12) | Triglyceride | −0.18 (−0.26, -0.09, p=1.0 x 10-4) | −0.09 (−0.17, 0.007, p=0.03) | 0.03 (−0.05, 0.11, p=0.42) | −0.04 (−0.12, 0.04, p=0.36) |