Skip to main content
Figure 1 | Lipids in Health and Disease

Figure 1

From: Dihydrotestosterone induces SREBP-1 expression and lipogenesis through the phosphoinositide 3-kinase/Akt pathway in HaCaT cells

Figure 1

The effects of the PI3K inhibitor ( LY294002 ) and ERK inhibitor ( PD98059 ) on DHT - induced expression of SREBP-1 in HaCaT cells. (A) LY294002 and PD98059 distinctly inhibited the DHT-induced protein expressions of p-Akt and p-ERK, respectively. (B) LY294002 inhibited the DHT-induced expression of SREBP-1 mRNA, while PD98059 has no significant effect on the DHT-induced mRNA expression of SREBP-1. (C) LY294002 inhibited the DHT-induced protein expression of SREBP-1, while PD98059 has no significant effect on the DHT-induced expression of protein SREBP-1. Data are means±SD of three independent experiments. * P < 0.01 vs. untreated control group; #P < 0.05 vs. DHT group.

Back to article page

Lipids in Health and Disease

ISSN: 1476-511X