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Table 3 SNPs and serum lipid levels and age-on-set

From: Association studies of several cholesterol-related genes (ABCA1, CETP and LIPC) with serum lipids and risk of Alzheimer’s disease

Parameter ABCA1R219K LIPC-250 G/A CETP Taq1B
RR RK KK RK + KK GG GA AA GA + AA B1B1 B1B2 B2B2 B1B2 + B1B1
Serum lipid levels TG (mmol/L) 1.39 ± 0.80 1.33 ± 0.57 1.20 ± 0.60 1.31 ± 0.58 1.24 ± 0.63 1.35 ± 0.69 1.50 ± 0.55 1.37 ± 0.68 1.25 ± 0.53 1.38 ± 0.70 1.32 ± 0.71 1.34 ± 0.67
TC (mmol/L) 4.22 ± 0.97 4.34 ± 0.99 4.31 ± 0.96 4.34 ± 0.99 4.12 ± 0.89 4.32 ± 0.99 4.45 ± 1.03 4.34 ± 1.00 4.21 ± 0.98 4.30 ± 0.95 4.39 ± 1.18 4.28 ± 0.96
HDL-C (mmol/L) 1.27 ± 0.28 1.39 ± 0.24a 1.76 ± 0.41 1.45 ± 0.31a* 1.35 ± 0.33 1.39 ± 0.30 1.41 ± 0.37 1.40 ± 0.31 1.37 ± 0.43c 1.21 ± 0.32 1.46 ± 0.35c* 1.24 ± 0.35d
LDL-C (mmol/L) 2.35 ± 0.72 2.49 ± 0.76 2.44 ± 0.75 2.48 ± 0.75 2.29 ± 0.73 2.45 ± 0.74 2.58 ± 0.75 2.47 ± 0.74 2.38 ± 0.73 2.45 ± 0.73 2.44 ± 0.86 2.43 ± 0.73
apoA-I (g/L) 1.11 ± 0.25 1.20 ± 0.23a 1.39 ± 0.25 1.24 ± 0.25a* 1.11 ± 0.25 1.20 ± 0.24b 1.29 ± 0.34b* 1.21 ± 0.25b 1.22 ± 0.29 1.17 ± 0.24 1.25 ± 0.28 1.18 ± 0.25
apoB (g/L) 0.79 ± 0.23 0.80 ± 0.22 0.78 ± 0.23 0.80 ± 0.22 0.77 ± 0.25 0.80 ± 0.22 0.83 ± 0.22 0.80 ± 0.22 0.78 ± 0.20 0.79 ± 0.23 0.84 ± 0.26 0.79 ± 0.22
Age-on-set (years)   73.2 ± 7.89 72.6 ± 6.92 73.2 ± 6.43 72.6 ± 6.82 73.2 ± 8.36 73.1 ± 6.87 70.9 ± 7.34 72.8 ± 6.94 73.0 ± 7.04 72.8 ± 7.76 72.9 ± 6.04 72.9 ± 7.49
  1. aP < 0.05 in comparison with RR genotype, a*P < 0.01 in comparison with RR genotype.
  2. bP < 0.05 in comparison with GG genotype, b*P < 0.01 in comparison with GG genotype.
  3. cP < 0.05 in comparison with B1B2 genotype, c*P < 0.01 in comparison with B1B2 genotype.
  4. dP < 0.05 in comparison with B2B2 genotype.