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Table 3 SNPs and serum lipid levels and age-on-set

From: Association studies of several cholesterol-related genes (ABCA1, CETP and LIPC) with serum lipids and risk of Alzheimer’s disease

Parameter

ABCA1R219K

LIPC-250 G/A

CETP Taq1B

RR

RK

KK

RK + KK

GG

GA

AA

GA + AA

B1B1

B1B2

B2B2

B1B2 + B1B1

Serum lipid levels

TG (mmol/L)

1.39 ± 0.80

1.33 ± 0.57

1.20 ± 0.60

1.31 ± 0.58

1.24 ± 0.63

1.35 ± 0.69

1.50 ± 0.55

1.37 ± 0.68

1.25 ± 0.53

1.38 ± 0.70

1.32 ± 0.71

1.34 ± 0.67

TC (mmol/L)

4.22 ± 0.97

4.34 ± 0.99

4.31 ± 0.96

4.34 ± 0.99

4.12 ± 0.89

4.32 ± 0.99

4.45 ± 1.03

4.34 ± 1.00

4.21 ± 0.98

4.30 ± 0.95

4.39 ± 1.18

4.28 ± 0.96

HDL-C (mmol/L)

1.27 ± 0.28

1.39 ± 0.24a

1.76 ± 0.41

1.45 ± 0.31a*

1.35 ± 0.33

1.39 ± 0.30

1.41 ± 0.37

1.40 ± 0.31

1.37 ± 0.43c

1.21 ± 0.32

1.46 ± 0.35c*

1.24 ± 0.35d

LDL-C (mmol/L)

2.35 ± 0.72

2.49 ± 0.76

2.44 ± 0.75

2.48 ± 0.75

2.29 ± 0.73

2.45 ± 0.74

2.58 ± 0.75

2.47 ± 0.74

2.38 ± 0.73

2.45 ± 0.73

2.44 ± 0.86

2.43 ± 0.73

apoA-I (g/L)

1.11 ± 0.25

1.20 ± 0.23a

1.39 ± 0.25

1.24 ± 0.25a*

1.11 ± 0.25

1.20 ± 0.24b

1.29 ± 0.34b*

1.21 ± 0.25b

1.22 ± 0.29

1.17 ± 0.24

1.25 ± 0.28

1.18 ± 0.25

apoB (g/L)

0.79 ± 0.23

0.80 ± 0.22

0.78 ± 0.23

0.80 ± 0.22

0.77 ± 0.25

0.80 ± 0.22

0.83 ± 0.22

0.80 ± 0.22

0.78 ± 0.20

0.79 ± 0.23

0.84 ± 0.26

0.79 ± 0.22

Age-on-set (years)

 

73.2 ± 7.89

72.6 ± 6.92

73.2 ± 6.43

72.6 ± 6.82

73.2 ± 8.36

73.1 ± 6.87

70.9 ± 7.34

72.8 ± 6.94

73.0 ± 7.04

72.8 ± 7.76

72.9 ± 6.04

72.9 ± 7.49

  1. aP < 0.05 in comparison with RR genotype, a*P < 0.01 in comparison with RR genotype.
  2. bP < 0.05 in comparison with GG genotype, b*P < 0.01 in comparison with GG genotype.
  3. cP < 0.05 in comparison with B1B2 genotype, c*P < 0.01 in comparison with B1B2 genotype.
  4. dP < 0.05 in comparison with B2B2 genotype.