Figure 2From: Inhibitory effect of the combination therapy of simvastatin and pinocembrin on atherosclerosis in apoE-deficient miceThe combination therapy inhibited the body weight gain and decreased serum lipid in the ApoE−/− mice. The ApoE−/− mice were fed high fat diet and given vehicle alone, simvastatin (10 mg/kg), pinocembrin (20 mg/kg ), or the combination of simvastatin (5 mg/kg) and pinocembrin (20 mg/kg) per day for 14 weeks. A: body weight for each mouse was measured at the end of experiment. B-D: the levels of serum lipid. Data are presented as the mean ± SEM (n = 8). *P < 0.05, **P < 0.01 versus vehicle-treated group; #P < 0.05, ##P < 0.01 versus simvastatin treatment.Back to article page