Figure 3

Effect of the combination of simvastatin and pinocembrin on the levels of NO, ET, SOD and MDA in serum of apoE^−/− mice. The mice were treated as in Figure 2 and the levels of NO (A), ET (B) , SOD (C) and MDA (D) in serum were measured as described as in materials and methods. Data are presented as the mean ± SEM (n = 8). ^*P < 0.05, ^**P < 0.01 versus vehicle-treated group; ^#P < 0.05, ^##P < 0.01 versus simvastatin treatment. SOD: superoxide dismutase, MDA: malondialdehyde, NO: nitric oxide , ET: endothelin.