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Figure 4 | Lipids in Health and Disease

Figure 4

From: Mitochondrial function is involved in regulation of cholesterol efflux to apolipoprotein (apo)A-I from murine RAW 264.7 macrophages

Figure 4

The effect of oligomycin (10μM; 3 h) on A) fold-change of genes involved in cholesterol metabolism and lipoprotein signalling in RAW 264.7 macrophages, compared with control cells, as judged by Q-PCR analysis of genes implicated in the cholesterol efflux, biosynthesis and esterification pathways; B) incorporation of [3H]oleate (10μM) into the cholesteryl ester pool, measured in the presence of absence of acetylated LDL (50μg ml-1; 3 h); C) incorporation of [14C]acetate into free cholesterol, cholesteryl ester, fatty acids, phospholipids and triacylglycerol (3 h) and D) induction of apoptosis in RAW 264.7 murine macrophages. Values are the mean±SEM of between three to six independent experiments. *p<0.05, **p<0.01 and ***p<0.001 compared with control macrophages.

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