Regulation of lipid metabolism-related gene expression in whole blood cells of normo- and dyslipidemic men after fish oil supplementation

Table 3 Expression ratios of lipid metabolism-related genes

Gene	Gene symbol	Entrez_ID	RefSeq_ID	dyslipidemic			normolipidemic			Function
				Ratio	Ratio	Ratio	Ratio	Ratio	Ratio
				t_4h:t₀	t₁:t₀	t₁₂:t₀	t_4h:t₀	t₁:t₀	t₁₂:t₀
Transcription factors
Peroxisome proliferator-activated receptor alpha	PPARA	5465	NM_001001928.2	−8.19^*	2.72^**	-	-	-	-	Regulation of the lipid metabolism
Peroxisome proliferator-activated receptor alpha	PPARA	5465	NM_005036.4	−8.19^*	2.72^**	-	-	-	-
Retinoic X receptor RXR-alpha	RXRA	6256	NM_002957.4	-	−4.50^*	-	3.14^*	3.79^*
Retinoic acid receptor RXR-gamma	RXRG	6258	NM_006917.3	3.16^***	4.79^***	4.11^***	−3.19^**	-	−2.03^**
Hepatocyte nuclear factor 6	HNF6	3175	NM_004498.1	−2.27^*	−4.89^*	−3.43^*	-	-	-
Hepatocyte nuclear factor 1-beta	HNF1B	6928	NM_000458.2	-	−3.64^*	−2.56^*	-	-	-
Triacylglycerol synthesis
2-acylglycerol O-acyltransferase 3	MOGAT3	346606	NM_178176.2	-	−27.07^*	−3.48^*	-	-	-	TG synthesis
2-acylglycerol O-acyltransferase 2	MOGAT2	80168	NM_025098.2	−3.08^*	-	-	-	-	-
Diacylglycerol O-acyltransferase 1	DGAT1	8694	NM_012079.4	-	−2.67^*	-	-	-	-
HDL-C metabolism
Phospholipid transfer protein	PLTP	5360	NM_006227.2	-	3.30^*	4.15^*	-	-	-	Modify HDL-C particles size
Phospholipid transfer protein	PLTP	5360	NM_182676.1	-	3.30^*	4.15^*	-	-	-	Modify HDL-C particles size
Cholesterol metabolism
ATP-binding cassette sub-family G member 5	ABCG5	64240	NM_022436.2	-	4.06^*	5.34^*	-	-	-	Cholesterol efflux
sterol O-acyltransferase 1	SOAT1	6646	NM_003101.4	-	−2.45^*	−2.37^**	-	-	-	Cholesterol synthesis

Expression ratios were displayed for genes which were differentially expressed after four hours (t_4h), one week (t₁) and twelve weeks (t₁₂) of fish oil supplementation in normolipidemic and dyslipidemic men.
-: no regulation.
^*: p = 0.05.
^**: p < 0.05.
^***: p < 0.01.

ISSN: 1476-511X