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Figure 2 | Lipids in Health and Disease

Figure 2

From: Dual functions of Insig proteins in cholesterol homeostasis

Figure 2

Dual functions of Insigs in cholesterol metabolism. Insig proteins exert their dual functions in cholesterol metabolism through binding to SCAP or HMG-CoA reductase. When sterols are over-accumulation, Insigs’ binding to SCAP prevents delivery of SCAP/SREBP complex to the Golgi. For this reason, transcriptional genes are needed for uptake and synthesis of cholesterol, fatty acids, phospholipids and triglycerides decline. Insigs’ binding to HMG-CoA reductase leads to the ubiquitination/degradation of the reductase. The degradation of HMG-CoA reductase inhibits cholesterol synthesis.

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