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Table 3 Summary of cytogenetic effect of LI10903F in mammalian cells

From: Efficacy of an herbal formulation LI10903F containing Dolichos biflorus and Piper betle extracts on weight management

Test Test Parameters Negative control LI10903F 2000mg/kg Cyclophosphamide 40 mg/kg
Mammalian Erythrocyte Micronucleus Test No. of immature Erythrocytes scored 2000 2000 2000
No. of Micronuclei present in immature erythrocytes 0.60±0.54 0.80±0.49 45.80±4.44
Test Test Parameters Negative control LI10903F 5000μg/ml Mitomycin C 0.2 μg/ml
Mammalian Chromosome Aberration Test No. of lymphocytes scored 100 100 100
  % Numerical Aberrations 0 1.50±0.71 30.50*±7.78
  No. of cells with one structural aberration 0 1.50±0.71 39.00*±5.66
  No. of cells with two structural aberrations 0.50±0.71 0.50±0.71 38.00*±4.24
  % Mitotic Index 3.65±0.12 2.65±0.21 1.30*±0.14
  1. ANOVA, * Significant (p<0.05).