Table 3 Summary of cytogenetic effect of LI10903F in mammalian cells
Test | Test Parameters | Negative control | LI10903F 2000mg/kg | Cyclophosphamide 40 mg/kg |
|---|---|---|---|---|
Mammalian Erythrocyte Micronucleus Test | No. of immature Erythrocytes scored | 2000 | 2000 | 2000 |
No. of Micronuclei present in immature erythrocytes | 0.60±0.54 | 0.80±0.49 | 45.80±4.44 | |
Test | Test Parameters | Negative control | LI10903F 5000μg/ml | Mitomycin C 0.2 μg/ml |
Mammalian Chromosome Aberration Test | No. of lymphocytes scored | 100 | 100 | 100 |
|  | % Numerical Aberrations | 0 | 1.50±0.71 | 30.50*±7.78 |
|  | No. of cells with one structural aberration | 0 | 1.50±0.71 | 39.00*±5.66 |
|  | No. of cells with two structural aberrations | 0.50±0.71 | 0.50±0.71 | 38.00*±4.24 |
|  | % Mitotic Index | 3.65±0.12 | 2.65±0.21 | 1.30*±0.14 |