Microsomal triglyceride transfer protein gene -493G/T polymorphism and its association with serum lipid levels in Bama Zhuang long-living families in China

Pan, Shang-Ling; Luo, Xiao-Qiu; Lu, Ze-Ping; Lu, Shao-Hua; Luo, Huan; Liu, Cheng-Wu; Hu, Cai-You; Yang, Ming; Du, Li-Li; Song, Zhen; Pang, Guo-Fang; Wu, Hua-Yu; Huang, Jin-Bo; Peng, Jun-Hua; Yin, Rui-Xing

doi:10.1186/1476-511X-11-177

Lipids in Health and Disease

Table 7 Correlation between serum lipid parameters and environmental risk factors in different families

From: Microsomal triglyceride transfer protein gene -493G/T polymorphism and its association with serum lipid levels in Bama Zhuang long-living families in China

Lipid	Relative factor	Unstandardized coefficient	Standard error	Standardized coefficient	t	P
Bama, all
TC	Waist	0.011	0.003	0.115	3.645	0.000
	DBP	0.009	0.002	0.113	5.198	0.000
	Age	0.006	0.001	0.157	6.772	0.000
	Hip	0.019	0.004	0.140	4.811	0.000
	Genotype	0.101	0.048	0.042	2.115	0.035
TG	Waist	0.020	0.003	0.243	7.540	0.000
	Age	−0.005	0.001	−0.161	−6.425	0.000
	DBP	0.005	0.002	0.075	3.336	0.001
	Sex	−0.100	0.037	−0.058	−2.741	0.006
	BMI	0.018	0.007	0.074	2.478	0.013
HDL-C	BMI	−0.015	0.003	−0.129	−5.944	0.000
	Age	0.001	0.000	0.084	3.767	0.000
	DBP	0.002	0.001	0.051	2.208	0.027
LDL-C	Age	0.007	0.001	0.213	9.573	0.000
	Hip	0.017	0.003	0.141	4.977	0.000
	BMI	0.021	0.007	0.081	2.827	0.005
	Sex	0.126	0.037	0.071	3.389	0.001
	DBP	0.005	0.002	0.063	2.842	0.005
	Genotype	0.098	0.042	0.047	2.343	0.019
BLF
TC	Age	0.006	0.001	0.149	4.812	0.000
	Hip	0.021	0.005	0.150	4.122	0.000
	DBP	0.008	0.002	0.096	3.364	0.001
TG	Sex	−0.117	0.050	−0.066	−2.324	0.020
	Waist	0.017	0.004	0.200	4.907	0.000
	Age	−0.005	0.001	−0.143	−4.243	0.000
	DBP	0.005	0.002	0.074	2.515	0.012
HDL-C	BMI	−0.014	0.003	−0.111	−4.035	0.000
	SBP	0.001	0.000	0.082	2.992	0.003
	Genotype	0.055	0.026	0.057	2.088	0.037
LDL-C	Age	0.008	0.001	0.235	8.931	0.000
	Hip	0.016	0.004	0.137	3.966	0.000
	BMI	0.018	0.009	0.069	1.993	0.046
BNLF
TC	Waist	0.031	0.004	0.310	7.071	0.000
	Age	0.005	0.002	0.121	2.708	0.007
	Sex	0.354	0.082	0.175	4.330	0.000
	DBP	0.011	0.004	0.135	2.942	0.003
TG	Waist	0.033	0.003	0.430	9.966	0.000
	Age	−0.006	0.001	−0.211	−4.888	0.000
HDL-C	Sex	0.162	0.035	0.207	4.588	0.000
	Age	0.003	0.001	0.224	4.865	0.000
	Waist	−0.011	0.003	−0.277	−3.342	0.001
	Chest	0.013	0.004	0.295	3.646	0.000
	BMI	−0.021	0.009	−0.178	−2.425	0.016
LDL-C	Waist	0.027	0.004	0.318	7.420	0.000
	Age	0.006	0.001	0.177	4.155	0.000
	Sex	0.253	0.069	0.146	3.694	0.000
BNZLF
TC	DBP	0.018	0.004	0.199	4.045	0.000
	Age	0.008	0.002	0.214	4.553	0.000
	Hip	0.022	0.011	0.157	2.081	0.038
	Chest	0.020	0.010	0.152	1.969	0.050
TG	DBP	0.011	0.004	0.158	3.034	0.003
	Age	−0.006	0.002	−0.205	−3.988	0.000
	Waist	0.026	0.005	0.292	5.473	0.000
HDL-C	none
LDL-C	Age	0.009	0.002	0.281	5.944	0.000
	DBP	0.011	0.004	0.147	2.975	0.003
	Hip	0.028	0.006	0.233	4.877	0.000
	Genotype	0.246	0.100	0.113	2.475	0.014
Pingguo, all
TC	BMI	0.060	0.009	0.214	6.947	0.000
	Age	0.007	0.001	0.193	6.206	0.000
	Sex	−0.153	0.061	−0.079	−2.516	0.012
TG	BMI	0.066	0.008	0.259	8.189	0.000
	Sex	−0.259	0.054	−0.146	−4.781	0.000
	DBP	0.008	0.002	0.113	3.590	0.000
	Age	−0.003	0.001	−0.098	−3.183	0.002
	Waist	0.007	0.002	0.089	2.913	0.004
HDL-C	Age	0.002	0.000	0.149	4.768	0.000
	BMI	−0.012	0.004	−0.106	−3.381	0.001
LDL-C	Age	0.006	0.001	0.181	5.870	0.000
	BMI	0.037	0.007	0.159	5.147	0.000
PLF
TC	BMI	0.053	0.015	0.182	3.542	0.000
	Age	0.006	0.001	0.168	4.211	0.000
	Chest	0.016	0.006	0.133	2.593	0.010
TG	Waist	0.034	0.004	0.361	8.969	0.000
	Age	−0.005	0.001	−0.146	−3.647	0.000
	Sex	−0.225	0.069	−0.132	−3.279	0.001
HDL-C	SBP	0.002	0.001	0.161	3.858	0000
	Waist	−0.005	0.002	−0.117	−2.811	0.005
LDL-C	BMI	0.053	0.010	0.218	5.396	0.000
	Age	0.005	0.001	0.183	4.534	0.000
PNLF
TC	Age	0.010	0.002	0.199	4.215	0.000
	BMI	0.038	0.013	0.140	2.847	0.005
	DBP	0.009	0.004	0.102	2.059	0.040
TG	BMI	0.070	0.012	0.284	6.005	0.000
	Sex	−0.266	0.085	−0.143	−3.126	0.002
	DBP	0.011	0.004	0.142	2.979	0.003
HDL-C	Age	0.004	0.001	0.206	4.336	0.000
	BMI	−0.013	0.005	−0.120	−2.520	0.012
LDL-C	Age	0.009	0.002	0.232	4.755	0.000
	Sex	−0.162	0.082	−0.096	−1.971	0.049
Total population
TC	Waist	0.009	0.002	0.090	4.255	0.000
	DBP	0.011	0.002	0.132	7.301	0.000
	Age	0.006	0.001	0.162	8.880	0.000
	BMI	0.040	0.006	0.133	6.453	0.000
TG	BMI	0.043	0.005	0.172	8.309	0.000
	Sex	−0.149	0.030	−0.085	−4.892	0.000
	Waist	0.012	0.002	0.143	6.702	0.000
	Age	−0.004	0.001	−0.120	−6.280	0.000
	DBP	0.007	0.001	0.100	5.447	0.000
HDL-C	Age	0.002	0.000	0.115	5.951	0.000
	BMI	−0.012	0.003	−0.099	−4.576	0.000
	DBP	0.001	0.001	0.042	2.202	0.028
	Waist	−0.002	0.001	−0.045	−2.009	0.045
LDL-C	Age	0.007	0.001	0.021	10.938	0.000
	BMI	0.032	0.005	0.123	6.251	0.000
	DBP	0.006	0.001	0.087	4.698	0.000
	Hip	0.007	0.002	0.069	3.594	0.000
	Sex	0.095	0.031	0.053	3.015	0.003
	Genotype	0.075	0.034	0.036	2.186	0.029

BLF, Bama long-lived families; BNLF, Bama non-long-lived families; BNZLF, Bama non-Zhuang long-lived families; PLF, Pingguo long-lived families; PNLF, Pingguo non-long-lived families; BMI, body mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure; TC, total cholesterol; TG, triglyceride; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol.

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ISSN: 1476-511X

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