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Table 2 Percent change from baseline in lipids, lipoproteins, lipid and apolipoprotein ratios and hs-CRP after 6 weeks of treatment (Full Analysis Set population)

From: Ezetimibe/simvastatin 10/40 mg versus atorvastatin 40 mg in high cardiovascular risk patients with primary hypercholesterolemia: a randomized, double-blind, active-controlled, multicenter study

 

Final absolute lipid value

LS mean% change

  
 

EZ/Simva

10/40 mg

Atorvastatin

40 mg

EZ/Simva 10/40 mg

Atorvastatin 40 mg

Between-treatment difference*

p -value

LDL-C, mmol/L (mg/dL)

2.32

(89.75)

2.79

(107.81)

-26.81

-11.81

-15.00

< 0.001

Total cholesterol, mmol/L (mg/dL)

4.45 (171.67)

4.84

(186.83)

-15.97

-7.73

-8.24

< 0.001

Triglycerides†‡, mmol/L (mg/dL)

1.40 (124.00)

1.34

(119.00)

-5.41

-7.54

2.13

0.593

HDL-C, mmol/L (mg/dL)

1.39

(53.54)

1.35

(51.94)

5.37

2.89

2.48

0.211

Non-HDL-C, mmol/L (mg/dL)

3.06

(118.13)

3.49

(134.89)

-20. 50

-10.88

-11.62

< 0.001

Apo B, g/L (mg/dL)

1.00

(99.72)

1.08

(108.52)

-17.23

-9.53

-7.69

0.002

Apo A-I, g/L (mg/dL)

1.58

(158.71)

1.51

(151.14)

2.56

-2.69

5.25

< 0.001

LDL-C/HDL-C

1.77

2.20

-28.77

-12.66

-16.1

< 0.001

Total C/HDL-C

3.35

3.77

-18.63

-8.60

-10.02

< 0.001

non-HDL-C/HDL-C

2.35

2.77

-24.41

-11.20

-13.21

< 0.001

Apo B/Apo A-I

0.65

0.73

-18.59

-5.67

-12.91

< 0.001

hs-CRP†‡, mg/L

1.70

1.80

-6.18

-8.86

2.68

0.785

  1. Apo, apolipoprotein; BMI, body mass index; EZ, ezetimibe; HDL-C, high-density lipoprotein cholesterol; hs-CRP, high-sensitivity C-reactive protein; LDL-C, low-density lipoprotein cholesterol; LS, least squares; simva, simvastatin
  2. *EZ/Simva (10/40 mg) - Atorvastatin 40 mg based on the least squares mean from a constrained LDA model with terms for treatment, time, time-by-treatment interaction, stratum and time-by-stratum interactions
  3. Final absolute values are medians
  4. Data were transformed by the natural logarithm; the difference in least squares means was based on the difference in the back transformed model-based least squares means and the associated confidence interval was calculated using the delta method. Geometric mean percent changes from baseline levels were calculated based on back-transformation via exponentiation of the model-based least squares means and expressed as (geometric mean - 1) multiplied by 100