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Figure 2 | Lipids in Health and Disease

Figure 2

From: Multiple roles of dihomo-γ-linolenic acid against proliferation diseases

Figure 2

Metabolism of dihomo-γ-linolenic acid. In mammal tissues and cells, LA is converted to AA by an alternating sequence of Δ6 desaturation, chain elongation and Δ5 desaturation. Dietary GLA bypasses the rate-limited Δ6 desaturation step and is quickly elongated to DGLA by elongase, with only a very limited amount being desaturated to AA by Δ5 desaturase. DGLA can be converted to PGE1 via the cyclooxygenase pathway and/or converted to 15-HETrE via the 15-lipoxygenase pathway.

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