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Figure 1 | Lipids in Health and Disease

Figure 1

From: Ameliorative effects of polyunsaturated fatty acids against palmitic acid-induced insulin resistance in L6 skeletal muscle cells

Figure 1

Palmitic acid downregulates IR expression and 2DG uptake activity.

Differentiated L6 cells were incubated with the indicated concentrations of palmitic acid for the indicated times. Dose-dependent effect of palmitic acid on (A) IR expression detected by western blotting, and (B) cell viability determined by crystal violet staining. (C) Time-dependent effect of palmitic acid on IR expression determined by western blotting. (D) Time-dependent effects of palmitic acid on 2DG uptake activity in the absence or presence of 100 nM insulin. * and ** indicate significant difference vs control at p < 0.05 and p < 0.01, respectively, for panel (B). Different letters indicate significant changes (p < 0.05) for panel (D).

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Lipids in Health and Disease

ISSN: 1476-511X