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Figure 4 | Lipids in Health and Disease

Figure 4

From: Ameliorative effects of polyunsaturated fatty acids against palmitic acid-induced insulin resistance in L6 skeletal muscle cells

Figure 4

Effects of arachidonic acid and other fatty acids on palmitic acid-induced decreases in 2DG uptake activity. Differentiated L6 myotubes were treated with 750 μM palmitic acid without or with the indicated fatty acids [(A) 750 μM stearic, palmitoleic, oleic, linoleic or α-linolenic acid; or 100 μM docosahexaenoic and eicosapentaenoic acid; (B) 10 and 50 μM arachidonic, eicosapentaenoic, or docosahexaenoic acid)] for 14 h. (C) Differentiated L6 myotubes were treated with 10-100 μM arachidonic acid as in (A). After treatment with the fatty acids, 2DG uptake activity was measured in the absence or presence of 100 nM insulin. Different letters indicate significant changes (p < 0.05).

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Lipids in Health and Disease

ISSN: 1476-511X