Skip to main content

Advertisement

Table 5 Effect of rutin (RT) and/or ascorbic acid (AA) on kidney nucleic acids and total protein levels in high-cholesterol diet (HCD) fed rats following 6 weeks of supplementation

From: Gender difference following high cholesterol diet induced renal injury and the protective role of rutin and ascorbic acid combination in Wistar albino rats

Treatment (in rat chow) DNA (μg/100 mg) RNA (μg/100 mg) Total protein (mg/100 mg)
  Male Female Male Female Male Female
Control 101.35 ± 18.33 110.56 ± 17.93 266.30 ± 26.60 240.16 ± 19.00 12.21 ± 0.47 11.26 ± 0.63
RT (0.2%) 108.33 ± 24.25 117.22 ± 12.08 271.22 ± 27.50 254.10 ± 11.80 12.15 ± 0.49 11.63 ± 0.43
AA (0.4%) 110.25 ± 18.05 114.21 ± 21.35 278.77 ± 17.28 248.52 ± 13.58 11.84 ± 0.53 11.95 ± 0.24
RT (0.1%) + AA (0.2%) 114.35 ± 17.37 112.60 ± 21.77 269.24 ± 31.53 250.20 ± 13.05 12.20 ± 0.60 11.53 ± 0.56
HCD (1% cholesterol + 0.5% cholic acid) 76.07 ± 15.99 75.64 ± 16.37 a 247.01 ± 13.17 186.95 ± 19.04 a 11.45 ± 0.35 10.64 ± 0.35
RT (0.2%) + HCD 81.45 ± 10.83 b 79.63 ± 12.47 ab 252.52 ± 20.72 192.11 ± 13.22 ab 11.54 ± 0.28 10.80 ± 0.31 b
AA (0.4%) + HCD 79.62 ± 11.54 c 84.46 ± 9.00 ac 255.66 ± 18.87 193.82 ± 20.91 ac 11.76 ± 0.37 10.96 ± 0.15 c
RT (0.1%) + AA (0.2%) + HCD 86.64 ± 11.89 d 102.49 ± 14.25 e 258.09 ± 21.65 219.12 ± 15.86 ade 11.87 ± 0.31 11.15 ± 0.24
  1. Data were expressed as Mean ± S.D and analyzed using one-way ANOVA followed by Student Newman-Keuls method as post hoc test. Six rats were used in each group. aAll treated groups vs. Control; bRT + HCD vs RT group; cAA + HCD vs AA group; dRT + AA + HCD vs RT + AA group; eRT + HCD, AA + HCD and RT + AA + HCD vs HCD