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Table 6 Effect of rutin (RT) and/or ascorbic acid (AA) on kidney MDA and GSH levels in high-cholesterol diet (HCD) fed rats following 6 weeks of supplementation

From: Gender difference following high cholesterol diet induced renal injury and the protective role of rutin and ascorbic acid combination in Wistar albino rats

Treatment (in rat chow) MDA (mmol/g) GSH (nmol/100 mg)
  Male Female Male Female
Control 168.77 ± 22.10 178.80 ± 15.99 131.68 ± 14.04 110.84 ± 18.16
RT (0.2%) 175.40 ± 19.88 184.13 ± 25.61 129.19 ± 9.45 122.87 ± 24.24
AA (0.4%) 164.19 ± 18.62 186.53 ± 25.54 128.14 ± 15.03 125.35 ± 39.96
RT (0.1%) + AA (0.2%) 161.67 ± 12.66 185.44 ± 29.42 126.87 ± 12.26 134.76 ± 15.95
HCD (1% cholesterol + 0.5% cholic acid) 204.91 ± 26.35 a 253.80 ± 15.06 a 94.93 ± 11.91 a 79.56 ± 11.65
RT (0.2%) + HCD 194.50 ± 18.43 235.69 ± 11.26 ab 98.29 ± 9.85 ab 82.71 ± 13.96 b
AA (0.4%) + HCD 182.48 ± 14.50 230.15 ± 13.94 ac 101.28 ± 12.98 ace 91.79 ± 12.32
RT (0.1%) + AA (0.2%) + HCD 164.44 ± 16.49 220.06 ± 16.02 ade 117.71 ± 14.37 e 106.01 ± 19.25
  1. Data were expressed as Mean ± S.D and analyzed using one-way ANOVA followed by Student Newman-Keuls method as post hoc test. Six rats were used in each group. aAll treated groups vs. Control; bRT + HCD vs RT group; cAA + HCD vs AA group; dRT + AA + HCD vs RT + AA group; eRT + HCD, AA + HCD and RT + AA + HCD vs HCD