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Table 6 Effect of rutin (RT) and/or ascorbic acid (AA) on kidney MDA and GSH levels in high-cholesterol diet (HCD) fed rats following 6 weeks of supplementation

From: Gender difference following high cholesterol diet induced renal injury and the protective role of rutin and ascorbic acid combination in Wistar albino rats

Treatment

(in rat chow)

MDA (mmol/g)

GSH (nmol/100 mg)

 

Male

Female

Male

Female

Control

168.77 ± 22.10

178.80 ± 15.99

131.68 ± 14.04

110.84 ± 18.16

RT (0.2%)

175.40 ± 19.88

184.13 ± 25.61

129.19 ± 9.45

122.87 ± 24.24

AA (0.4%)

164.19 ± 18.62

186.53 ± 25.54

128.14 ± 15.03

125.35 ± 39.96

RT (0.1%) + AA (0.2%)

161.67 ± 12.66

185.44 ± 29.42

126.87 ± 12.26

134.76 ± 15.95

HCD (1% cholesterol + 0.5% cholic acid)

204.91 ± 26.35 a

253.80 ± 15.06 a

94.93 ± 11.91 a

79.56 ± 11.65

RT (0.2%) + HCD

194.50 ± 18.43

235.69 ± 11.26 ab

98.29 ± 9.85 ab

82.71 ± 13.96 b

AA (0.4%) + HCD

182.48 ± 14.50

230.15 ± 13.94 ac

101.28 ± 12.98 ace

91.79 ± 12.32

RT (0.1%) + AA (0.2%) + HCD

164.44 ± 16.49

220.06 ± 16.02 ade

117.71 ± 14.37 e

106.01 ± 19.25

  1. Data were expressed as Mean ± S.D and analyzed using one-way ANOVA followed by Student Newman-Keuls method as post hoc test. Six rats were used in each group. aAll treated groups vs. Control; bRT + HCD vs RT group; cAA + HCD vs AA group; dRT + AA + HCD vs RT + AA group; eRT + HCD, AA + HCD and RT + AA + HCD vs HCD
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Lipids in Health and Disease

ISSN: 1476-511X