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Table 3 Plasma concentration of total free aminothiols (glutathione, homocysteine, cysteine and cysteinylglycine) at baseline and after the 28-day treatment with fenofibrate or placebo

From: Treatment of chronic hemodialysis patients with low-dose fenofibrate effectively reduces plasma lipids and affects plasma redox status

Parameter

Healthy controls*

Baseline

After Placebo

After Fenofibrate

Glutathione [nmol/mL]

5.3 ± 1.2

3.3 ± 0.9

3.4 ± 1.1

4.2 ± 1.4#$

Homocysteine [nmol/mL]

2.6 ± 1.7

6.6 ± 3.9

7.8 ± 5.0

9.0 ± 7.4##

Cysteine [nmol/mL]

47 ± 22

160 ± 48

163 ± 47

167 ± 51

Cysteinylglycine [nmol/ml]

7 ± 2

24 ± 4.5

23 ± 4

25 ± 7

  1. * healthy controls – historic cohort from Bald E et al. [19]
  2. # p = 0.01 vs baseline; $ p = 0.02 vs placebo
  3. ## p = 0.04 vs baseline
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Lipids in Health and Disease

ISSN: 1476-511X