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Table 1 FTIR interpretation of CBZ SLN comparative to pure drug physical mixture and polymers

From: Formulation and evaluation of chitosan solid lipid nanoparticles of carbamazepine

Functional group

Drug

SLN formulation

Physical mixture

Tristearin

Phospholipon 80 H

N-H stretch

3464 cm-1

3444.8 cm-1

3464.15 cm-1

Absent

Absent

C = 0 stretch

1677 cm-1

1635.64 cm-1

1678.07 cm-1

Absent

Absent

Aromatic C-H stretch

3080.75 cm-1

Absent

2954.95 cm-1

2954.95 cm-1

2954.95 cm-1

C = C stretch

1605 cm-1

1635.64,1558.48 cm-1

1604.77 cm-1

Absent

Absent

C≡N

1384.89 cm-1

1373.32 cm-1

1384.89 cm-1

Absent

Absent

CHO aldehydic group

Absent

1732.80 cm-1

1735.93 cm-1

1728.22 cm-1

1725.92 cm-1

Methylene C-H asym stretch

Absent

Absent

2916.37 cm-1

2914.44 cm-1

2916.37 cm-1

Polymeric

Absent

3444.87 cm-1

3280.92 cm-1

Absent

3398.57 cm-1

     

3377.26 cm-1

O-H stretch

 

3419.97 cm-1

  

3281.93 cm-1