Table 4 Effect of a single dose administration of CBZ SLN on reducing the duration of epileptic phases in Maximal Electric Shock (MES) model
From: Formulation and evaluation of chitosan solid lipid nanoparticles of carbamazepine
S. No. | Phases in MES model | Control (Mean ± SEM) (Sec) | Standard (Mean ± SEM) (Sec) | Test (Mean ± SEM) (Sec) | Significance |
|---|---|---|---|---|---|
1 | Flexion | 1.167 ± 0.1667 | Nil | Nil | (P<0.05) significant |
2 | Extension | 26.50 ± 1.607 | 0.0 ± 0 | 0.0 ± 0 | (P<0.05) significant |
3 | Clonus | 18.83 ± 0.7923 | 15.83 ± 2.787 | 4.667 ± 1.211 | (P<0.05) significant |
4 | Stupor | 72 ± 2.828 | 35.67 ± 6.377 | 24.33 ± 7.528 | (P<0.05) significant |
5 | Recovery | Recovered | Recovered | Recovered | significant |