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Table 4 Effect of a single dose administration of CBZ SLN on reducing the duration of epileptic phases in Maximal Electric Shock (MES) model

From: Formulation and evaluation of chitosan solid lipid nanoparticles of carbamazepine

S. No. Phases in MES model Control (Mean ± SEM) (Sec) Standard (Mean ± SEM) (Sec) Test (Mean ± SEM) (Sec) Significance
1 Flexion 1.167 ± 0.1667 Nil Nil (P<0.05) significant
2 Extension 26.50 ± 1.607 0.0 ± 0 0.0 ± 0 (P<0.05) significant
3 Clonus 18.83 ± 0.7923 15.83 ± 2.787 4.667 ± 1.211 (P<0.05) significant
4 Stupor 72 ± 2.828 35.67 ± 6.377 24.33 ± 7.528 (P<0.05) significant
5 Recovery Recovered Recovered Recovered significant