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Table 1 Fatty acid composition (wt%) in heart of rats after 50 weeks of diet administration

From: Long-term treatment with the pan-PPAR agonist tetradecylthioacetic acid or fish oil is associated with increased cardiac content of n-3 fatty acids in rat

  

Dietary supplementationa

Statistical significance of variance ratio (P)b, effects of

 

Control

TTA

FO

TTA + FO

TTA

FO

TTA*FO

Total FA (μg/g tissue)

22196 ± 2706c

24087 ± 1394

22578 ± 1503

24185 ± 1613

0.002

0.66

0.79

C16:0

11.1 ± 1.3

11.0 ± 1.1

10.0 ± 1.2

10.8 ± 0.6

0.25

0.05

0.22

C18:0

19.7 ± 1.2

18.8 ± 1.1

19.8 ± 1.1

18.9 ± 0.9

0.005

0.55

1.00

MUFA

10.2 ± 3.6

11.2 ± 3.1

8.4 ± 3.0

6.7 ± 2.6

0.70

0.001

0.14

C16:1n-7

0.24 ± 0.11

0.32 ± 0.11

0.21 ± 0.10

0.16 ± 0.09

0.70

0.002

0.03

C18:1n-7

2.6 ± 0.1

1.8 ± 0.2

2.4 ± 0.2

2.1 ± 0.2

<0.001

0.79

<0.001

C16:1n-9

0.10 ± 0.05

0.15 ± 0.04

0.11 ± 0.06

0.10 ± 0.04

0.27

0.13

0.09

C18:1n-9 (OA)

6.9 ± 3.4

8.5 ± 2.9

5.2 ± 2.7

3.9 ± 2.3

0.85

<0.001

0.08

C20:3n-9 (MA)

0.10 ± 0.01

0.55 ± 0.28

0.06 ± 0.01

0.05 ± 0.01

<0.001

<0.001

<0.001

C18:2n-6 (LA)

15.7 ± 1.0

17.2 ± 2.0

9.2 ± 1.0

5.8 ± 1.2

0.03

<0.001

<0.001

C18:3n-3 (ALA)

0.15 ± 0.06

0.20 ± 0.06

0.14 ± 0.06

0.10 ± 0.06

0.57

0.004

0.02

C18:4n-3

0.4 ± 0.3k

0.3 ± 0.3k

82.8 ± 38.0k

89.4 ± 30.4k

0.64

<0.001

0.64

TTA

ND

2.8 ± 1.0

ND

1.7 ± 0.5

   

TTA:1n-8

ND

0.79 ± 0.49

ND

0.12 ± 0.04

   

n-3 PUFA/n-6 PUFA ratio

0.39 ± 0.04

0.55 ± 0.13

1.6 ± 0.2

3.9 ± 1.1

<0.001

<0.001

<0.001

Δ5 desaturase index (n-6)d

49.0 ± 4.6

9.8 ± 1.8

38.5 ± 5.8

10.6 ± 1.5

<0.001

<0.001

<0.001

Δ5 desaturase index (n-3)e

2.6 ± 0.4

4.2 ± 0.7

24.5 ± 4.3

36.4 ± 7.0

<0.001

<0.001

<0.001

Δ6 desaturase index (n-6)f

1.1 ± 0.4k

2.6 ± 0.7k

2.5 ± 0.7k

7.9 ± 2.0k

<0.001

<0.001

<0.001

Δ6 desaturase index (n-3)g

2.7 ± 2.3k

1.7 ± 1.4k

0.61 ± 0.10

0.94 ± 0.19

<0.001

<0.001

<0.001

Δ9 desaturase index (C16)h

0.02 ± 0.01

0.03 ± 0.01

0.02 ± 0.01

0.01 ± 0.01

0.73

0.001

0.003

Δ9 desaturase index (C18)i

0.36 ± 0.22

0.46 ± 0.18

0.27 ± 0.16

0.21 ± 0.14

0.71

0.001

0.13

Anti-inflammatory indexj

68.8 ± 6.7

155 ± 37.6

274 ± 50.1

866 ± 234

<0.001

<0.001

<0.001

  1. Abbreviations: TTA, tetradecylthioacetic acid; FO, fish oil; FA, fatty acids; MUFA, monounsaturated fatty acids; OA, oleic acid; MA, mead acid; LA, linoleic acid; ALA, α-linolenic acid; PUFA, polyunsaturated fatty acids; ND, not detectable.
  2. a n=12 in each group.
  3. b P-values from two-way ANOVA.
  4. c Values are mean ± SD.
  5. d C20:4n-6/C20:3n-6 (an indirect index of Δ5 desaturase activity based on n-6 PUFA).
  6. e C20:5n-3/C20:4n-3 (an indirect index of Δ5 desaturase activity based on n-3 PUFA).
  7. f C18:3n-6/C18:2n-6 (an indirect index of Δ6 desaturase activity based on n-6 PUFA).
  8. g C18:4n-3/C18:3n-3 (an indirect index of Δ6 desaturase activity based on n-3 PUFA).
  9. h C16:1n-7/C16:0 (an indirect index of Δ9 desaturase activity based on C16 SFA/MUFA).
  10. i C18:1n-9/C18:0 (an indirect index of Δ9 desaturase activity based on C18 SFA/MUFA).
  11. j ((C22:6n-3 + C22:5n-3 + C20:3n-6 + C20:5n-3)/C20:4n-6)*100.
  12. k Values are *10-3.
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Lipids in Health and Disease

ISSN: 1476-511X