Skip to main content

Table 2 Fatty acid composition (wt%) in liver of rats after 50 weeks of diet administration

From: Long-term treatment with the pan-PPAR agonist tetradecylthioacetic acid or fish oil is associated with increased cardiac content of n-3 fatty acids in rat

  

Dietary supplementationa

Statistical significance of variance ratio (P)b, effects of

 

Control

TTA

FO

TTA + FO

TTA

FO

TTA*FO

Total FA (μg/g tissue)

42287 ± 4330c

39177 ± 2734

43285 ± 4935

41488 ± 4163

0.10

0.27

0.66

C16:0

18.8 ± 0.7

19.8 ± 1.2

16.9 ± 0.6

19.5 ± 0.7

<0.001

0.001

0.01

C18:0

16.1 ± 1.2

14.1 ± 1.0

16.0 ± 0.8

13.3 ± 1.2

<0.001

0.22

0.38

MUFA

17.8 ± 2.2

22.4 ± 3.1

12.4 ± 1.5

17.0 ± 1.6

<0.001

<0.001

0.99

C16:1n-7

0.61 ± 0.38

0.69 ± 0.30

0.37 ± 0.11

0.40 ± 0.08

0.52

0.007

0.76

C18:1n-7

1.7 ± 0.3

1.4 ± 0.1

1.2 ± 0.1

1.1 ± 0.0

<0.001

<0.001

0.09

C16:1n-9

0.20 ± 0.06

0.41 ± 0.07

0.20 ± 0.03

0.37 ± 0.08

<0.001

0.45

0.33

C18:1n-9 (OA)

14.7 ± 1.8

19.5 ± 2.9

10.0 ± 1.4

14.7 ± 1.6

<0.001

<0.001

0.95

C20:3n-9 (MA)

0.23 ± 0.02

1.15 ± 0.45

0.10 ± 0.01

0.15 ± 0.03

<0.001

<0.001

<0.001

C18:2n-6 (LA)

15.5 ± 1.3

9.3 ± 2.0

11.9 ± 0.6

11.7 ± 0.7

<0.001

0.19

<0.001

C18:3n-3 (ALA)

0.35 ± 0.06

0.08 ± 0.03

0.34 ± 0.06

0.17 ± 0.03

<0.001

0.03

0.006

C18:4n-3

0.02 ± 0.00

0.01 ± 0.00

0.12 ± 0.03

0.07 ± 0.01

<0.001

<0.001

0.002

TTA

ND

1.8 ± 0.4

ND

1.3 ± 1.1

   

TTA:1n-8

ND

0.97 ± 0.18

ND

0.56 ± 0.17

   

n-3 PUFA/n-6 PUFA ratio

0.18 ± 0.02

0.16 ± 0.04

1.20 ± 0.18

1.02 ± 0.13

0.02

<0.001

0.05

Δ5 desaturase index (n-6)d

29.6 ± 8.1

11.8 ± 2.1

24.5 ± 5.2

7.8 ± 1.1

<0.001

0.02

0.77

Δ5 desaturase index (n-3)e

3.6 ± 0.6

3.4 ± 0.9

34.9 ± 5.1

35.5 ± 6.3

0.91

<0.001

0.78

Δ6 desaturase index (n-6)f

14.0 ± 3.2k

47.9 ± 14.9k

4.4 ± 1.2k

16.9 ± 2.8k

<0.001

<0.001

0.001

Δ6 desaturase index (n-3)g

18.1 ± 3.9

9.8 ± 3.5

3.0 ± 0.5

2.5 ± 0.3

<0.001

<0.001

<0.001

Δ9 desaturase index (C16)h

0.03 ± 0.02

0.03 ± 0.01

0.02 ± 0.01

0.02 ± 0.00

0.92

0.01

0.66

Δ9 desaturase index (C18)i

0.92 ± 0.17

1.40 ± 0.29

0.63 ± 0.11

1.12 ± 0.24

<0.001

0.001

0.90

Anti-inflammatory indexj

34.0 ± 2.8

32.7 ± 7.5

254 ± 53.5

253 ± 47.1

0.91

<0.001

0.99

  1. Abbreviations: TTA, tetradecylthioacetic acid; FO, fish oil; FA, fatty acids; MUFA, monounsaturated fatty acids; OA, oleic acid; MA, mead acid; LA, linoleic acid; ALA, α-linolenic acid; PUFA, polyunsaturated fatty acids; ND, not detectable.
  2. a n=8 in each group.
  3. b P-values from two-way ANOVA.
  4. c Values are mean ± SD.
  5. d C20:4n-6/C20:3n-6 (an indirect index of Δ5 desaturase activity based on n-6 PUFA).
  6. e C20:5n-3/C20:4n-3 (an indirect index of Δ5 desaturase activity based on n-3 PUFA).
  7. f C18:3n-6/C18:2n-6 (an indirect index of Δ6 desaturase activity based on n-6 PUFA).
  8. g C18:4n-3/C18:3n-3 (an indirect index of Δ6 desaturase activity based on n-3 PUFA).
  9. h C16:1n-7/C16:0 (an indirect index of Δ9 desaturase activity based on C16 SFA/MUFA).
  10. i C18:1n-9/C18:0 (an indirect index of Δ9 desaturase activity based on C18 SFA/MUFA).
  11. j ((C22:6n-3 + C22:5n-3 + C20:3n-6 + C20:5n-3)/C20:4n-6)*100.
  12. k Values are *10-3.
Back to article page

Lipids in Health and Disease

ISSN: 1476-511X