Long-term treatment with the pan-PPAR agonist tetradecylthioacetic acid or fish oil is associated with increased cardiac content of n-3 fatty acids in rat

Table 3 Enzyme activity (nmol/min/mg protein) in heart of rats after 50 weeks of diet administration

		Dietary supplementation^a			Statistical significance of variance ratio (P)^b, effects of
	Control	TTA	FO	TTA + FO	TTA	FO	TTA*FO
CPT-I	2.79 ± 0.26^c	1.69 ± 0.38	2.54 ± 0.12	1.75 ± 0.14	<0.001	0.22	0.06
CPT-I (with malonyl-CoA)	1.89 ± 0.21	1.23 ± 0.28	1.77 ± 0.14	1.31 ± 0.13	<0.001	0.73	0.14
CPT-II	10.79 ± 1.03	23.55 ± 3.15	12.40 ± 2.33	22.39 ± 4.32	<0.001	0.82	0.15
ACOX	1.65 ± 0.31	4.53 ± 1.16	4.61 ± 1.41	8.47 ± 1.37	<0.001	<0.001	0.19
GPAT	0.25 ± 0.06	0.43 ± 0.09	0.39 ± 0.09	0.64 ± 0.14	<0.001	<0.001	0.37
FAS	0.04 ± 0.01	0.09 ± 0.01	0.06 ± 0.02	0.10 ± 0.02	<0.001	0.01	0.34

Abbreviations: TTA, tetradecylthioacetic acid; FO, fish oil; CPT-I, carnitine palmitoyltransferase I; CPT-II, carnitine palmitoyltransferase II; ACOX, fatty acyl-CoA oxidase; GPAT, glycerol-3-phosphate acyltransferase; FAS, fatty acid synthase.
^a n=10 in each group.
^b P-values from two-way ANOVA.
^c Values are mean ± SD.

ISSN: 1476-511X