MYLIP p.N342S polymorphism is not associated with lipid profile in the Brazilian population

Table 1 General characteristics according to MYLIP rs9370867 genotypes

General population	Genotypes			p value
(n= 1295, 100%)	GG (n= 547)	GA (n= 571)	AA (n= 177)
Age (years)	44.1 ± 10.9	45.1 ± 10.7	45.8 ± 10.5	0.14
Gender, female (%)	52.7	54.1	55.9	0.72
Ethnicity^a (%)
White	30.7	47.2	22.1
Intermediate	45.2	44.4	10.4	<0.001
Black	72.7	24.2	3.1
Other	47.9	45.3	6.8
Hypertension^b (%)	48.6	45.2	36.1	0.05
Diabetes^c (%)	6.4	8.1	6.2	0.49
Hyperlipidemia^d (%)	26.3	27.1	27.7	0.33
Increased arterial stiffness^e (%)	16.1	14.9	10.2	0.20
Smokers^f (%)	24.9	24.5	24.3	0.58
Body mass index^g (Kg/m²)	26.4 ± 5.2	26.3 ± 4.7	25.9 ± 4.5	0.60
Patients submitted to coronary angiography	Genotypes			p value
(n= 1425, 100%)	GG (n= 545)	GA (n= 633)	AA (n= 247)
Age (years)	59.5 ± 10.6	60.2 ± 10.1	60.1 ± 10.3	0.55
Gender, female (%)	41.7	41.2	36.0	0.29
Ethnicity (%)
White	31.6	47.7	20.7
Intermediate	44.8	42.3	12.9	<0.001
Black	63.2	30.9	5.9
Other	91.2	8.8	0
Hypertension (%)	74.6	73.4	67.1	0.08
Diabetes (%)	35.4	34.1	34.2	0.56
Hyperlipidemia (%)	57.6	61.1	56.2	0.69
Smoker (%)	32.7	37.0	38.1	0.21
Body mass index (Kg/m²)	27.8 ± 4.9	27.6 ± 4.7	27.7 ± 4.9	0.67

^aEthnicity was categorized in White, Black, Intermediate (person with admixture between White and Black) and other (Amerindians and Oriental descent).
^bHypertension was defined as mean systolic blood pressure ≥ 140 mmHg and/or diastolic blood pressure ≥ 90 mmHg and/or use of anti-hypertension drugs.
^cDiabetes was defined as fasting glucose ≥ 126 mg/dL and/or use of hypoglycemic drugs.
^dHyperlipidemia was defined as total-cholesterol ≥ 240 mg/dL, low density lipoprotein-cholesterol ≥ 160 mg/dL, and/or use of hypolipidemic drugs.
^eIncreased arterial stiffness was defined as pulse wave velocity ≥ 12 m/s.
^fIndividuals who had ever smoked more than five cigarettes per day for the last a year were classified as smokers.
^gAdjusted for age and gender.

ISSN: 1476-511X