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Table 2 Serum lipid levels among three smoking status by Mt5178 C/A genotypes

From: Mitochondrial DNA 5178 C/A polymorphism influences the effects of habitual smoking on the risk of dyslipidemia in middle-aged Japanese men

 

Smoking status

P for trend

 

Never- or ex-smokers

1-20 cigarettes smoked per day

>20 cigarettes smoked per day

Mt5178C

N = 142

N = 70

N = 27

 

HDL cholesterol

55.9 ± 1.1

52.6 ± 1.6

52.6 ± 2.6

0.089

HDL cholesterol †

56.5 ± 1.1

52.1 ± 1.5

51.0 ± 2.5

0.008

HDL cholesterol ‡

55.6 ± 1.6

52.2 ± 1.8

51.1 ± 2.7

0.037

LDL cholesterol ‡

122.2 ± 2.9

116.8 ± 4.1

130.7 ± 6.7

0.672

LDL cholesterol †

121.8 ± 2.9

117.2 ± 4.2

131.9 ± 6.8

0.514

LDL cholesterol ‡

126.7 ± 4.5

119.7 ± 5.0

134.6 ± 7.4

0.795

Triglyceride

134.7 ± 7.7

139.6 ± 10.9

139.5 ± 17.6

0.717

Triglyceride†

133.3 ± 7.5

141.0 ± 10.7

143.2 ± 17.3

0.502

Triglyceride‡

125.6 ± 11.6

135.8 ± 13.0

138.5 ± 19.3

0.394

Mt5178A

N = 92

N = 40

N = 23

 

HDL cholesterol

57.5 ± 1.7

56.2 ± 2.6

51.5 ± 3.4

0.136

HDL cholesterol †

58.0 ± 1.6

54.1 ± 2.5

53.0 ± 3.2

0.100

HDL cholesterol ‡

56.3 ± 2.6

52.1 ± 2.9

50.7 ± 3.8

0.071

LDL cholesterol

115.8 ± 3.2

119.6 ± 4.8

123.2 ± 6.4

0.266

LDL cholesterol †

115.1 ± 3.2

122.1 ± 4.9

121.8 ± 6.3

0.221

LDL cholesterol ‡

118.3 ± 5.1

122.6 ± 5.8

123.3 ± 7.6

0.392

Triglyceride

120.4 ± 8.6

130.9 ± 13.1

230.7 ± 17.3*,**

<0.001

Triglyceride†

119.4 ± 8.5

136.8 ± 13.1

224.6 ± 17.0*,**

<0.001

Triglyceride‡

114.5 ± 13.6

137.4 ± 15.4

223.5 ± 20.4*,**

<0.001

  1. HDL; high-density lipoprotein. LDL; low-density lipoprotein. †HDL cholesterol levels, †LDL cholesterol levels and †triglyceride levels are given as least-square mean ± S.E. adjusted for age, body mass index; ‡HDL cholesterol levels , ‡LDL cholesterol levels and ‡triglyceride levels are given as least-square mean ± S.E. adjusted for age, body mass index, alcohol consumption, coffee consumption and antihypertensive medication use. The Bonferroni correction for multiple comparison was applied. *P < 0.001 vs. never- or ex-smokers, **P < 0.001 vs. current smokers who smoked 1–20 cigarettes per day.
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Lipids in Health and Disease

ISSN: 1476-511X