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Table 3 Odds ratios (ORs) and 95% confidence intervals (CIs) for hypo-HDL cholesterolemia by Mt5178 C/A genotype and smoking status

From: Mitochondrial DNA 5178 C/A polymorphism influences the effects of habitual smoking on the risk of dyslipidemia in middle-aged Japanese men

Genotype and number of cigarette smoked daily

Frequency

OR (95% CI)

Adjusted OR† (95% CI)

Adjusted OR‡ (95% CI)

Normal HDLcholesterol (HDL cholesterol ≥ 40 mg/dl)

Hypo-HDLcholesterolemia (HDL cholesterol < 40 mg/dl)

Mt5178C

     

0 (never- or ex-smoker)

133 (93.7)

9 (6.3)

1 (reference)

1 (reference)

1 (reference)

1-20

58 (82.9)

12 (17.1)

3.058 (1.221-7.654)*

3.317 (1.303-8.446)*

2.771 (1.039-7.388)*

>20

20 (74.1)

7 (25.9)

5.172 (1.732-15.44)**

8.048 (2.244-28.87)**

8.339 (1.993-34.89)**

   

P for trend = 0.001

P for trend < 0.001

P for trend = 0.002

Mt5178A

     

0 (never- or ex-smoker)

82 (89.1)

10 (10.9)

1 (reference)

1 (reference)

1 (reference)

1-20

34 (85.0)

6 (15.0)

1.447 (0.488-4.297)

2.143 (0.664-6.918)

1.703 (0.481-6.027)

>20

20 (87.0)

3 (13.0)

1.230 (0.310-4.888)

1.158 (0.281-4.781)

1.264 (0.289-5.533)

   

P for trend = 0.629

P for trend = 0.563

P for trend = 0.577

  1. †OR adjusted for age and body mass index.
  2. ‡OR adjusted for age, body mass index, habitual alcohol consumption, coffee consumption and antihypertensive medication.
  3. *P < 0.05, **P < 0.005.