Table 4 Odds ratios (ORs) and 95% confidence intervals (CIs) for hyper-LDL cholesterolemia by Mt5178 C/A genotype and smoking status
Genotype and number of cigarette smoked daily | Frequency | OR (95% CI) | Adjusted OR† (95% CI) | Adjusted OR‡ (95% CI) | |
|---|---|---|---|---|---|
Normal LDLcholesterol (LDL cholesterol < 140 mg/dl) | Hyper-LDLcholesterolemia (LDL cholesterol ≥ 140 mg/dl) | ||||
Mt5178C | |||||
0 (never- or ex-smoker) | 107 (75.4) | 35 (24.6) | 1 (reference) | 1 (reference) | 1 (reference) |
1-20 | 53 (75.7) | 17 (24.3) | 0.981 (0.504-1.910) | 0.972 (0.492-1.923) | 0.944 (0.460-1.940) |
>20 | 16 (59.3) | 11 (40.7) | 2.102 (0.892-4.953) | 2.181 (0.889-5.348) | 2.506 (0.973-6.457) |
P for trend = 0.181 | P for trend = 0.160 | P for trend = 0.164 | |||
Mt5178A | |||||
0 (never- or ex-smoker) | 75 (81.5) | 17 (18.5) | 1 (reference) | 1 (reference) | 1 (reference) |
1-20 | 26 (65.0) | 14 (35.0) | 2.376 (1.029-5.482)* | 2.993 (1.222-7.330)* | 2.790 (1.080-7.206)* |
>20 | 14 (60.9) | 9 (39.1) | 2.836 (1.055-7.626)* | 2.982 (1.080-8.232)* | 2.908 (1.012-8.351)* |
P for trend = 0.017 | P for trend = 0.014 | P for trend = 0.035 | |||