Histology of mouse pancreas stained by Hematoxylin & Eosin. Normal islets of Langerhans (L) surrounded by exocrine portion (E) of pancreatic tissues in control mice (A). Destruction and distortion of endocrine cells in STZ-diabetic mice with the presence of necrotic cells and inflammatory cells (arrowhead) (B). C: Improvement in morphology of islets of Langerhans with α, β-amyrin (100 mg/kg) pretreatment in STZ-diabetic mice; D: Islets of Langerhans of diabetic mice treated with glibenclamide (10 mg/kg) showing restoration of normal cellular population. (H & E 400×), Bar: 20 μm.