Antihyperglycemic and hypolipidemic effects of α, β-amyrin, a triterpenoid mixture from Protium heptaphyllum in mice

Table 1 Effects of α, β-amyrin and glibenclamide treatments on blood glucose, total cholesterol and triglycerides in normal mice

Group	Dose (mg/kg)	Blood glucose (mg/dL)	Total Cholesterol (mg/dL)	Triglycerides (mg/dL)
Normal Control	-	114.50 ± 5.11	93.60 ± 11.66	143.10 ± 11.40
Vehicle Control	-	115.75 ± 5.61	96.00 ± 5.12	151.10 ± 14.62
α,β-amyrin	10 mg/kg	106.83 ± 1.47	97.63 ± 10.39	114.60 ± 8.19
α,β-amyrin	30 mg/kg	101.67 ± 2.55	92.75 ± 7.74	116.00 ± 8.01
α,β-amyrin	100 mg/kg	100.43 ± 4.92	72.57 ± 9.32^a,b	97.00 ± 9.76^a,b
Glibenclamide	10 mg/kg	87.14 ± 5.21^a,b	69.17 ± 2.18^a,b	82.38 ± 2.66 ^a,b

Each value represents the mean ± SEM, n = 8 mice. ^a p < 0.05 compared with normal control. ^b p < 0.05 compared with vehicle control.

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