Table 1 Baseline demographics and clinical characteristics
EZ/Simva 10/20 mg | Doubling statin dose | Rosuvastatin 10 mg | ||||
|---|---|---|---|---|---|---|
Obese subjects | n = 181 | n = 93 | n = 192 | |||
Sex, n (%) | ||||||
Male | 90 | (49.7) | 46 | (49.5) | 102 | (53.1) |
Female | 91 | (50.3) | 47 | (50.5) | 90 | (46.9) |
Age, years Mean (SD) | 63.3 | (8.2) | 63.5 | (8.5) | 63.3 | (8.2) |
Weight, kg Mean (SD) | 99.3 | (15.3) | 96.2 | (12.5) | 96.5 | (13.3) |
Body Mass Index (BMI, kg/m 2 ) | ||||||
Mean (SD) | 35.4 | (4.3) | 34.6 | (3.7) | 34.6 | (3.7) |
Race, n (%) | ||||||
American Indian or Alaska Native | 1 | (0.6) | 0 | (0.0) | 1 | (0.5) |
Black or African American | 4 | (2.2) | 1 | (1.1) | 1 | (0.5) |
Multi-Racial | 10 | (5.5) | 4 | (4.3) | 8 | (4.2) |
White | 166 | (91.7) | 88 | (94.6) | 182 | (94.8) |
Ethnicity, n (%) | ||||||
Hispanic or Latino | 19 | (10.5) | 9 | (9.7) | 22 | (11.5) |
Not Hispanic or Latino | 162 | (89.5) | 84 | (90.3) | 170 | (88.5) |
Clinical Characteristics, mg/dL | Mean | SD | Mean | SD | Mean | SD |
LDL-C | 97.9 | 22.4 | 99.3 | 22.0 | 95.7 | 19.1 |
Total cholesterol | 179.0 | 30.4 | 180.5 | 27.0 | 178.3 | 24.2 |
Triglycerides* | 149.0 | 74.4 | 136.0 | 77.2 | 143.5 | 74.4 |
HDL-C | 48.6 | 11.5 | 51.0 | 11.6 | 47.8 | 10.7 |
Non-HDL-C | 130.4 | 28.3 | 129.4 | 25.8 | 127.5 | 23.6 |
Apo B | 101.6 | 19.8 | 101.7 | 17.7 | 100.0 | 18.6 |
Apo A-I | 148.4 | 24.6 | 153.5 | 22.2 | 147.6 | 22.0 |
hs-CRP*, mg/L | 2.4 | 2.9 | 1.9 | 3.2 | 2.6 | 3.7 |
Non-obese subjects | n = 141 | n = 69 | n = 132 | |||
Sex, n (%) | ||||||
Male | 70 | (49.6) | 34 | (49.3) | 80 | (60.6) |
Female | 71 | (50.4) | 35 | (50.7) | 52 | (39.4) |
Age, years Mean (SD) | 65.2 | (9.3) | 66.2 | (7.9) | 64.0 | (8.6) |
Weight, kg Mean (SD) | 73.5 | (11.0) | 76.3 | (11.5) | 76.3 | (11.5) |
Body mass index (BMI, kg/m 2 ) | ||||||
Mean (SD) | 35.4 | (4.3) | 34.6 | (3.7) | 34.6 | (3.7) |
Race, n (%) | ||||||
American Indian or Alaska Native | 3 | (2.1) | 2 | (2.9) | 4 | (3.0) |
Black or African American | 1 | (0.7) | 1 | (1.4) | 1 | (0.8) |
Multi-Racial | 23 | (16.3) | 7 | (10.1) | 16 | (12.1) |
White | 114 | (80.9) | 59 | (85.5) | 111 | (84.1) |
Ethnicity, n (%) | ||||||
Hispanic or Latino | 45 | (31.9) | 16 | (23.2) | 32 | (24.2) |
Not Hispanic or Latino | 96 | (68.1) | 53 | (76.8) | 100 | (75.8) |
Clinical characteristics, mg/dL | Mean | SD | Mean | SD | Mean | SD |
LDL-C | 100.1 | 21.6 | 94.7 | 20.2 | 99.9 | 20.5 |
Total cholesterol | 180.5 | 30.9 | 173.0 | 26.3 | 178.7 | 28.7 |
Triglycerides* | 126.0 | 65.1 | 126.0 | 51.2 | 132.0 | 76.3 |
HDL-C | 52.6 | 15.8 | 50.6 | 12.7 | 50.5 | 13.3 |
Non-HDL-C | 127.9 | 26.9 | 122.4 | 25.3 | 128.2 | 26.4 |
Apo B | 101.7 | 20.4 | 98.9 | 20.1 | 101.0 | 20.0 |
Apo A-I | 152.7 | 32.9 | 153.1 | 28.2 | 149.4 | 27.3 |
hs-CRP*, mg/L | 1.6 | 2.9 | 2.0 | 2.2 | 1.6 | 2.3 |