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Table 3 Association of each ADRB2 polymorphism with lipid traits

From: Association of ADRB2 polymorphism with triglyceride levels in Tongans

SNP

Derived allele

Frequency

Total cholesterol (mg/dL)

HDL cholesterol (mg/dL)

LDL cholesterol (mg/dL)

Triglyceride

(mg/dL)

(mg/dL)

(mg/dL)

(mg/dL)

   

β

SE

P-value

β

SE

P-value

β

SE

P-value

β

SE

P-value

rs17778257

T

0.39

5.17

5.52

0.351

0.110

1.06

0.918

4.34

4.83

0.371

8.20

12.8

0.523

rs34623097

A

0.04

13.7

14.6

0.350

−2.88

2.78

0.302

3.60

12.8

0.779

70.1

33.3

0.037

rs2895795

A

0.52

−8.09

5.42

0.138

−0.0671

1.04

0.949

−6.18

4.75

0.196

−19.1

12.5

0.130

rs2053044

A

0.09

10.0

9.82

0.312

−0.128

1.88

0.946

6.35

8.61

0.462

36.3

22.6

0.111

rs11959427a

T

0.95

−8.00

13.5

0.557

1.70

2.60

0.503

−3.50

11.9

0.768

−36.1

31.2

0.250

rs1042711 (Arg19Cys)

T (Cys)

0.95

−7.97

13.5

0.557

1.74

2.58

0.503

−3.51

11.9

0.768

−36.1

31.2

0.250

rs1042713 (Gly16Arg)a

A (Arg)

0.42

5.70

5.30

0.285

0.400

1.00

0.720

4.50

4.70

0.344

13.9

12.5

0.267

rs1042714 (Glu27Gln)a

C (Gln)

0.96

−8.50

14.6

0.563

2.10

2.80

0.443

−5.20

12.8

0.683

−37.9

33.7

0.263

rs1042719

C

0.43

4.42

5.38

0.413

−0.102

1.03

0.921

2.30

4.72

0.627

23.7

12.3

0.057

rs1042720

A

0.61

−2.47

5.48

0.652

0.616

1.04

0.556

0.05

4.80

0.992

−23.8

12.5

0.059

  1. A multiple regression analysis adjusted for age, sex, and BMI was performed to examine the association of each polymorphism with each lipid trait; BMI Body Mass Index, HDL High Density Lipoprotein, LDL Low Density Lipoprotein.
  2. a The genotypes of subjects whose genotypes had not been determined by a molecular biology-based technique were imputed by using the MACH software.