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Figure 5 | Lipids in Health and Disease

Figure 5

From: Polyunsaturated fatty acid relatively decreases cholesterol content in THP-1 macrophage-derived foam cell: partly correlates with expression profile of CIDE and PAT members

Figure 5

Effects of PUFAs on the mRNA expressions of PPARγ transcriptional regulated proteins during THP-1 macrophage-derived foam cell formation. The THP-1 macrophages were pre-treated with different NEFA in advance, and then ox-LDL was added to facilitate foam cell formation. Total RNAs were extracted from both macrophages and foam cells and reverse-transcribed into cDNA. PPARγ, SR-A1, CD36, ABCA1 and apoAI were measured by real-time PCR. Data represent mean ± SEM (n = 3). P < 0.05 vs. the value in macrophages; P < 0.05 vs. the un-treated control.

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