Table 1 Descriptions of mice used in this study

Apoa1 KO

B6;129P2-Apoa1^tm1Unc/J (JAX® 002055)

C57BL/6 J

Apoe KO

B6.129P2-Apoe^tm1Unc/J (JAX® 002052) backcrossed to B6

C57BL/6 J

Tg(hLDLR)

Hemizygous male offspring of hemizygous B6;SJL-Tg(Mt1-LDLR)93-4Reh/AgnJ (JAX® #008850) males mated with B6SJLF1/J (JAX® #100012) females

Wild-type male littermates of Tg(hLDLR)

Ldlr KO

B6.129S7-Ldlr^tm1Her/J (JAX® 002207) backcrossed to B6

C57BL/6 J

Pcsk9 KO

B6;129S6-Pcsk9^tm1Jdh/J (JAX® 005993) backcrossed to B6

C57BL/6 J

Pcsk9 KO IRCM

B6 mice that lack the Pcsk9 proximal promoter and exon 1 region

C57BL/6 J

Pcsk9/Apoe double-KO

Apoe KO mice crossed to Pcsk9 KO IRCM mice

C57BL/6 J

Pcsk9/Ldlr double-KO

Ldlr KO mice crossed to Pcsk9 KO IRCM mice

C57BL/6 J