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Table 1 Descriptions of mice used in this study

From: Decreased APOE-containing HDL subfractions and cholesterol efflux capacity of serum in mice lacking Pcsk9

Mouse strain Control mice
Abbreviation Full name, description
Apoa1 KO B6;129P2-Apoa1tm1Unc/J (JAX® 002055) C57BL/6 J
Apoe KO B6.129P2-Apoetm1Unc/J (JAX® 002052) backcrossed to B6 C57BL/6 J
Tg(hLDLR) Hemizygous male offspring of hemizygous B6;SJL-Tg(Mt1-LDLR)93-4Reh/AgnJ (JAX® #008850) males mated with B6SJLF1/J (JAX® #100012) females Wild-type male littermates of Tg(hLDLR)
Ldlr KO B6.129S7-Ldlrtm1Her/J (JAX® 002207) backcrossed to B6 C57BL/6 J
Pcsk9 KO B6;129S6-Pcsk9tm1Jdh/J (JAX® 005993) backcrossed to B6 C57BL/6 J
Pcsk9 KO IRCM B6 mice that lack the Pcsk9 proximal promoter and exon 1 region C57BL/6 J
Pcsk9/Apoe double-KO Apoe KO mice crossed to Pcsk9 KO IRCM mice C57BL/6 J
Pcsk9/Ldlr double-KO Ldlr KO mice crossed to Pcsk9 KO IRCM mice C57BL/6 J
  1. C57BL/6 J is JAX® 000664.