Table 2 The effect of simvastatin on expression of genes involved in lipid metabolism in MiaPaCa-2 cells
Gene symbol | Product name and related functional pathway | RefSeq ID | Fold change after simvastatin | FDR | |
|---|---|---|---|---|---|
6 μM | 12 μM | ||||
HMGCS1 | 3-hydroxy-3-methylglutaryl-coenzyme A synthase (EC 2.3.3.10) | NM_002130.6 | 3.48 | 3.63 | 3.3 × 10-8 |
Mevalonate pathway (cholesterol synthesis) | |||||
HMGCR | 3-hydroxy-3-methylglutaryl-coenzyme A reductase (EC 1.1.1.34) | NM_000859.1 | 2.58 | 3.11 | 2.1 × 10-6 |
Mevalonate pathway (cholesterol synthesis) | |||||
MVD | Mevalonate pyrophosphate decarboxylase (EC 4.1.1.33) | NM_002461.1 | 2.31 | 2.39 | 3.4 × 10-7 |
Mevalonate pathway (cholesterol synthesis) | |||||
PPAP2A | Phosphatidic acid phosphatase 2a (EC 3.1.3.4) | NM_003711.2 | 1.79 | 2.25 | 3.3 × 10-5 |
Kennedy pathway (triacylglycerol synthesis) | |||||
AGPAT2 | 1-acyl-glycerol-phosphate acyltransferase 2 (EC 2.3.1.51) | NM_006412.3 | 1.71 | 2.01 | 5.0 × 10-5 |
Kennedy pathway (phospholipids and glycerolipids synthesis) | |||||
ACSS2 | Acyl-CoA synthetase short-chain family member 2 (EC 6.2.1.1) | NM_018677.2 | 2.16 | 2.22 | 1.7 × 10-6 |
Activation of long chain fatty acids | |||||
ABCA7 | ABC transporter sub-family A member 7 | NM_019112.3 | 1.67 | 2.03 | 2.3 × 10-5 |
Transporter involved in cholesterol and lipid homeostasis | |||||