Skip to main content
Figure 1 | Lipids in Health and Disease

Figure 1

From: Sildenafil ameliorates biomarkers of genotoxicity in an experimental model of spontaneous atherosclerosis

Figure 1

Effect of sildenafil treatment on superoxide anion production in MNC of apoE-/-mice. (A) Representative histogram from flow cytometric analysis using dihydroethidium (DHE) in control C57 wild-type (WT), apoE-/- vehicle and apoE-/- sildenafil; the log fluorescence (X axis) illustrates the intensity of fluorescence for the number of cells counted (note the higher scales in the apoE-/- vehicle histogram). A remarkable increase in the level of superoxide anions was observed in apoE-/- vehicle. Line colors correspond to bar colors below. (B) Bar graph showing mean fluorescence intensity (MFI, in a.u.). The values are presented as means ± SEM; 6 to 8 animals per group. **p < 0.01, ANOVA).

Back to article page

Lipids in Health and Disease

ISSN: 1476-511X